Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis

  1. B. Yu1,2,
  2. Y. Shao1,2,
  3. J. Zhang1,2,
  4. X.L. Dong1,
  5. W.L. Liu1,
  6. H. Yang1,3,
  7. L. Liu1,
  8. M.H. Li1,
  9. C.F. Yue1,
  10. Z.Y. Fang1,
  11. C. Zhang1,
  12. X.P. Hu2,
  13. B.C. Chen2,
  14. Q. Wu1,
  15. Y.W. Chen3,
  16. W. Zhang3,
  17. J. Wan1,5

Article first published online: 1 MAR 2010

DOI: 10.1111/j.1365-2133.2010.09675.x

Issue

British Journal of Dermatology

British Journal of Dermatology

Volume 162, Issue 5, pages 1038–1043, May 2010

Additional Information

How to Cite

Yu, B., Shao, Y., Zhang, J., Dong, X.L., Liu, W.L., Yang, H., Liu, L., Li, M.H., Yue, C.F., Fang, Z.Y., Zhang, C., Hu, X.P., Chen, B.C., Wu, Q., Chen, Y.W., Zhang, W. and Wan, J. (2010), Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. British Journal of Dermatology, 162: 1038–1043. doi: 10.1111/j.1365-2133.2010.09675.x

Author Information

  1. 1

    Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, No. 1120 Lianhua Road, Futian District, Shenzhen, Guangdong 518036, China

  2. 2

    Departments of Dermatology

  3. 3

    Clinical Laboratory, Shenzhen Hospital Peking University, Shenzhen, Guangdong 518036, China

  4. 5

    Department of Biochemistry, the Hong Kong University of Science and Technology, Hong Kong, China

*Jun Wan. E-mail: wanj@ust.hk

  1. Conflicts of interest None declared.

  2. B.Y. and Y.S. contributed equally to this work; W.Z. and J.W. contributed equally to this work.

Publication History

  1. Issue published online: 19 APR 2010
  2. Article first published online: 1 MAR 2010
  3. Accepted for publication 23 December 2009

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Keywords:

  • atopic dermatitis;
  • histamine receptor H4;
  • HRH4;
  • single nucleotide polymorphism

Summary

Background  Atopic dermatitis (AD) is a chronic skin disease affecting more than 15% of children and 2% of adults. A strong connection between genetic factors and AD has been described for a long time. Histamine receptor H4 (HRH4) has been shown to be related to different kinds of allergic and autoimmune disorders. However, an association between HRH4 and AD has not yet been reported.

Objectives  To examine a possible association between HRH4 and AD.

Methods  Genomic DNA from 301 patients with AD and 313 healthy controls was extracted and three exons of HRH4 were sequenced.

Results  We found three new single nucleotide polymorphisms (SNPs) in HRH4 which were significantly associated with AD: ss142022671 [odds ratio (OR) 1·87, 95% confidence interval (CI) 1·24–2·81; P = 0·002], ss142022677 (OR 4·40, 95% CI 2·42–8·00; P = 1·5 × 10−7) and ss142022679 (OR 4·26, 95% CI 2·38–7·61; P = 1·3 × 10−7). The SNPs ss142022677 and ss142022679 were found to be in strong linkage disequilibrium (D’ = 0·98; r2 = 0·92). Two-SNP haplotype analysis (ss142022677 and ss142022679) showed that the major AA haplotype was protective against AD (OR 0·22, 95% CI 0·12–0·40; P = 3·1 × 10−8) and the minor TT haplotype was significantly associated with AD (OR 4·13, 95% CI 2·27–7·54; P = 6·6 × 10−7). In addition, in a three-SNP haplotype analysis (ss142022671, ss142022677 and ss142022679), the major TAA haplotype was protective against AD (OR 0·46, 95% CI 0·31–0·69; P = 0·0001), while the complementary ATT haplotype was found to be significantly associated with AD (OR 3·81, 95% CI 2·03–7·14; P = 8·3 × 10−6).

Conclusions  Polymorphisms of ss142022671, ss142022677 and ss142022679 in HRH4 are associated with AD.

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