Conflicts of interest None declared.
Plant cysteine proteases that evoke itch activate protease-activated receptors
Article first published online: 20 MAY 2010
© 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists
British Journal of Dermatology
Volume 163, Issue 3, pages 532–535, September 2010
How to Cite
Reddy, V.B. and Lerner, E.A. (2010), Plant cysteine proteases that evoke itch activate protease-activated receptors. British Journal of Dermatology, 163: 532–535. doi: 10.1111/j.1365-2133.2010.09862.x
- Issue published online: 19 AUG 2010
- Article first published online: 20 MAY 2010
- Accepted for publication 30 April 2010
- cysteine protease;
- protease-activated receptor;
Background Bromelain, ficin and papain are cysteine proteases from plants that produce itch upon injection into skin. Their mechanism of action has not been considered previously.
Objectives To determine the mechanism by which these proteases function.
Methods The ability of these proteases to activate protease-activated receptors was determined by ratiometric calcium imaging.
Results We show here that bromelain, ficin and papain activate protease-activated receptors 2 and 4.
Conclusions Bromelain, ficin and papain function as signalling molecules and activate protease-activated receptors. Activation of these receptors is the likely mechanism by which these proteases evoke itch.