Funding sources The study did not receive any external funding.
Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children
Article first published online: 11 APR 2011
© 2011 The Authors. BJD © 2011 British Association of Dermatologists
British Journal of Dermatology
Volume 164, Issue 5, pages 1078–1082, May 2011
How to Cite
Peroni, D.G., Piacentini, G.L., Cametti, E., Chinellato, I. and Boner, A.L. (2011), Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. British Journal of Dermatology, 164: 1078–1082. doi: 10.1111/j.1365-2133.2010.10147.x
Conflicts of interest None declared.
- Issue published online: 26 APR 2011
- Article first published online: 11 APR 2011
- Accepted manuscript online: 18 NOV 2010 10:56AM EST
- Accepted for publication 14 November 2010
Background Vitamin D deficiency could be associated with the prevalence of atopic dermatitis (AD).
Objectives We carried out a study to see whether deficient/insufficient levels of vitamin D correlate with the severity of atopic skin disease.
Methods Using the SCORAD index, we evaluated the severity of disease in 37 children (17 girls and 20 boys) aged between 8 months and 12 years with AD, consecutively enrolled in the study. Serum levels of 25-hydroxyvitamin D [25(OH)D] were determined by a chemiluminescent method. Specific IgE (sIgE) to Staphylococcus aureus enterotoxins and sIgE to Malassezia furfur were assayed by the ImmunoCAP system. anova and the Pearson correlation test were used for statistical evaluation.
Results We found severe, moderate and mild AD in nine (24%), 13 (35%) and 15 (41%) children, respectively. Mean ± SD serum levels of 25(OH)D were significantly higher (P < 0·05) in patients with mild disease (36·9 ± 15·7 ng mL−1) compared with those with moderate (27·5 ± 8·3 ng mL−1) or severe AD (20·5 ± 5·9 ng mL−1). The prevalence of patients with sIgE to microbial antigens increased in relation to vitamin D deficiency and AD severity.
Conclusions These data suggest that vitamin D deficiency may be related to the severity of AD and advocate the need for studies evaluating the use of vitamin D as a potential treatment in patients with this disease.