Funding sources None.
Viral oncogenesis and its role in nonmelanoma skin cancer
Version of Record online: 13 MAY 2011
© 2011 The Authors. BJD © 2011 British Association of Dermatologists
British Journal of Dermatology
Volume 164, Issue 6, pages 1201–1213, June 2011
How to Cite
Tuttleton Arron, S., Jennings, L., Nindl, I., Rosl, F., Bouwes Bavinck, J.N., Seçkin, D., Trakatelli, M., Murphy, G.M. and for the Viral Working Group of the International Transplant Skin Cancer Collaborative (ITSCC) & Skin Care in Organ Transplant Patients, Europe (SCOPE) (2011), Viral oncogenesis and its role in nonmelanoma skin cancer. British Journal of Dermatology, 164: 1201–1213. doi: 10.1111/j.1365-2133.2011.10322.x
Conflicts of interest None declared.
S.T.A. and L.J. contributed equally to this work.
- Issue online: 25 MAY 2011
- Version of Record online: 13 MAY 2011
- Accepted manuscript online: 21 MAR 2011 01:20PM EST
- Accepted for publication 28 December 2010
In recent years, the contribution of viruses to cutaneous oncogenesis has steadily gained recognition. The archetype is human herpesvirus 8, which is well established as the causative agent in Kaposi sarcoma. Other viruses believed to play a role in nonmelanoma skin cancer include human papillomavirus and the recently described Merkel cell polyomavirus. We review the mechanisms by which these three viruses interact with the host cell, ultraviolet radiation and immunosuppression to result in carcinogenesis.