Funding sources None.
CLINICAL AND LABORATORY INVESTIGATIONS
Association between atopic dermatitis and obesity in adulthood
Article first published online: 6 FEB 2012
© 2011 The Authors BJD © 2011 British Association of Dermatologists
British Journal of Dermatology
Volume 166, Issue 3, pages 498–504, March 2012
How to Cite
Silverberg, J.I., Silverberg, N.B. and Lee-Wong, M. (2012), Association between atopic dermatitis and obesity in adulthood. British Journal of Dermatology, 166: 498–504. doi: 10.1111/j.1365-2133.2011.10694.x
Conflicts of interest None declared.
- Issue published online: 22 FEB 2012
- Article first published online: 6 FEB 2012
- Accepted manuscript online: 16 OCT 2011 10:20PM EST
- Accepted for publication , 4 October 2011
Background Obesity in early childhood is associated with increased risk for and severity of atopic dermatitis (AD).
Objective To determine whether obesity in adulthood is associated with risk of AD.
Methods This was a retrospective case–control study of 2090 adults using questionnaire, height and weight, and skin-prick testing between January 1994 and December 2003.
Results Obesity in adults was associated with increased AD [multinomial logistic regression: adjusted odds ratio (aOR) 1·43, 95% confidence interval (CI) 1·08–1·89; P = 0·01], but not nonatopic dermatitis (aOR 0·59, 95% CI 0·21–1·68; P = 0·32). Obesity was also associated with increased atopic asthma (aOR 1·98, 95% CI 1·47–2·66, P < 0·0001), but not associated with nonatopic asthma (P = 0·20), atopic or nonatopic rhinoconjunctivitis (P = 0·08 and 0·31, respectively), food allergies (P = 0·67 and 0·35, respectively) or atopy (P = 0·40). The association between obesity and AD remained significant even when controlling for history of asthma, rhinoconjunctivitis and food allergies (aOR 1·40, 95% CI 1·05–1·86; P = 0·02) or in subset analyses of subjects with AD alone (aOR 1·96, 95% CI 1·02–3·75; P = 0·04) and with comorbid asthma, rhinoconjunctivitis and/or food allergies (aOR 1·40, 95% CI 1·03–1·91; P = 0·03).
Conclusion Obesity in adulthood is associated with AD. Further studies are warranted to determine if weight loss may prevent or mitigate AD in adults.