Funding sources This study was financially supported by a research grant from the Comite Institucional de Recerca of the Research Foundation of Parc Taulí Hospital.
CLINICAL AND LABORATORY INVESTIGATIONS
Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis
Version of Record online: 25 MAY 2012
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 166, Issue 6, pages 1237–1244, June 2012
How to Cite
Romaní, J., Caixàs, A., Carrascosa, J.M., Ribera, M., Rigla, M. and Luelmo, J. (2012), Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis. British Journal of Dermatology, 166: 1237–1244. doi: 10.1111/j.1365-2133.2012.10883.x
Conflicts of interest None declared.
- Issue online: 25 MAY 2012
- Version of Record online: 25 MAY 2012
- Accepted manuscript online: 6 FEB 2012 06:25PM EST
- Accepted for publication 31 January 2012
Background Previous studies have shown increased prevalence of metabolic syndrome in patients with psoriasis.
Objectives To characterize the anthropometric and metabolic profile of Spanish patients with moderate to severe psoriasis compared with controls without psoriasis matched for gender, age and body mass index (BMI), and to evaluate the impact of narrowband ultraviolet B (NB-UVB) therapy on patient profiles.
Methods Baseline waist circumference, body fat composition, lipid, carbohydrate and calcium metabolism profile, inflammation markers, homocysteine, vitamins D, B6 and B12 and folic acid of 50 patients with psoriasis and 50 matched controls were recorded then evaluated after NB-UVB in patients with psoriasis and correlated with clinical outcome.
Results Despite very similar BMIs, 54% of patients met International Diabetes Foundation criteria for metabolic syndrome compared with 42% of controls (P = 0·01); body fat was 29·9% in patients and 28·0% in controls (P = 0·037), correlating with waist circumference; while patient atherogenic profiles were less favourable, with higher apolipoprotein B and low density lipoprotein cholesterol than controls, and both patients and controls showed insufficient vitamin D serum levels (< 20 ng mL−1). Mean improvement of Psoriasis Area and Severity Index (PASI) after NB-UVB was 78·2%. Ferritin, B12 and C-reactive protein decreased significantly after NB-UVB therapy. Vitamin D levels reached adequate levels after phototherapy; however, no relationship with PASI improvement was observed.
Conclusions We characterized inflammatory and atherogenic profiles of Spanish patients with psoriasis compared with matched controls. After NB-UVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated by enhancement of vitamin D synthesis.