Funding sources None.
Clinicopathological comparisons of index and second primary melanomas in paediatric and adult populations
Article first published online: 26 SEP 2012
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 167, Issue 4, pages 882–887, October 2012
How to Cite
Jung, G.W. and Weinstock, M.A. (2012), Clinicopathological comparisons of index and second primary melanomas in paediatric and adult populations. British Journal of Dermatology, 167: 882–887. doi: 10.1111/j.1365-2133.2012.11097.x
Conflicts of interest None declared.
- Issue published online: 26 SEP 2012
- Article first published online: 26 SEP 2012
- Accepted manuscript online: 20 JUN 2012 03:13PM EST
- Accepted for publication 30 May 2012
Summary Background The high incidence of cutaneous melanoma globally has sparked interest in the features associated with second primary melanomas (SPMs).
Objectives To identify differences and similarities between index and second primary melanomas while comparing the absolute and relative risk of subsequent melanoma development in paediatric and adult patients.
Methods A retrospective analysis of patients diagnosed with invasive malignant melanoma from 1973 to 2008 inclusive was completed with data obtained from the Surveillance, Epidemiology and End Results (SEER) database.
Results In total, 208 289 patients were diagnosed with invasive melanoma in the SEER database from 1973 to 2008, with subsequent primary melanomas diagnosed in 6888 (3·3%). The incidence of SPMs increased with increasing age of diagnosis of the patient’s first melanoma. However, the relative risk of developing a subsequent melanoma was nearly double for patients diagnosed with their first melanoma at the age of 19 years and younger compared with patients greater than the age of 19 years. Compared with a patient’s initial invasive melanoma, 44% of the subjects had a different melanoma subtype with their subsequent melanoma. SPMs were located in a different anatomical site from the index malignancy in 55% of patients. Nodular melanomas were more common as index melanomas compared with SPMs.
Conclusions Although invasive cutaneous melanoma is primarily a malignancy of adulthood, the heightened relative risk of SPMs in the paediatric population calls for careful long-term scrutiny in this latter population following an index melanoma diagnosis.