Data S1. Single nucleotide polymorphism selection and haplotype construction. Table S1 Primers and conditions for amplification of different genetic markers. List of restriction enzymes to characterize single nucleotide polymorphisms.

Data S2. Table S2 Extragenic COL7A1 haplotypes in the general Spanish population.

Data S3. Population growth rates (r) and proportion population sample (f) in different populations. Linkage disequilibrium (LD) analysis between c.6527insC and markers. Table S3A LD analyses for the c.6527insC mutation and markers flanking the COL7A1 locus. Table S3B Estimation of the time of the most recent common ancestor of the c.6527insC chromosomes in two different areas (given area and Spain).

BJD_11128_sm_DataS1-S3.pdf134KSupporting info item

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