Funding sources The authors acknowledge salary support provided by the NIH NCRR Laser and Medical Microbeam Program (LAMMP: P41EB05890), the NIH SBIRs 1R43RR030696-01A1, R01HD065536 and 1R43RR025985-01, the Military Photomedicine Program (AFOSR grant no. FA9550-08-1-0384), R01 AR054885, the Beckman Foundation and the Hazem Chehabi BLI Research Fellowship.
Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: a review
Version of Record online: 5 OCT 2012
© 2012 The Authors. BJD © 2012 British Association of Dermatologists 2012
British Journal of Dermatology
Volume 167, Issue 6, pages 1215–1223, December 2012
How to Cite
Sharif, S.A., Taydas, E., Mazhar, A., Rahimian, R., Kelly, K.M., Choi, B. and Durkin, A.J. (2012), Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: a review. British Journal of Dermatology, 167: 1215–1223. doi: 10.1111/j.1365-2133.2012.11139.x
Conflicts of interest A.J.D. is a cofounder of the company and owns equity interests in Modulated Imaging Inc., which collaborated in the development of the spatial frequency domain imaging (SFDI) system reviewed here.
- Issue online: 26 NOV 2012
- Version of Record online: 5 OCT 2012
- Accepted manuscript online: 14 JUL 2012 10:11AM EST
- Accepted for publication , 28 June 2012
Port-wine stain (PWS) birthmarks are one class of benign congenital vascular malformation. Laser therapy is the most successful treatment modality of PWS. Unfortunately, this approach has limited efficacy, with only 10% of patients experiencing complete blanching of the PWS. To address this problem, several research groups have developed technologies and methods designed to study treatment outcome and improve treatment efficacy. This article reviews seven optical imaging techniques currently in use or under development to assess treatment efficacy, focusing on: reflectance spectrophotometers/tristimulus colorimeters; laser Doppler flowmetry and laser Doppler imaging; cross-polarized diffuse reflectance colour imaging system; reflectance confocal microscopy; optical coherence tomography; spatial frequency domain imaging; and laser speckle imaging.