Small doses of ARA-C in the treatment of acute myeloid leukaemia: differentiation of myeloid leukaemia cells?
Version of Record online: 12 MAR 2008
British Journal of Haematology
Volume 51, Issue 1, pages 125–129, May 1982
How to Cite
Housset, M., Daniel, M. T. and Degos, L. (1982), Small doses of ARA-C in the treatment of acute myeloid leukaemia: differentiation of myeloid leukaemia cells?. British Journal of Haematology, 51: 125–129. doi: 10.1111/j.1365-2141.1982.tb07297.x
- Issue online: 12 MAR 2008
- Version of Record online: 12 MAR 2008
- Received 21 July 1981; accepted for publication 17 November 1981
Three patients with acute myeloid leukaemia were treated with small doses of ARA-C (10 mg/m2/12 h, subcutaneous injections) and complete remission was obtained. The small doses of ARA-C, the progressive evolution, the absence of aplasia before remission, the simultaneous presence of normal islets of promyelocytes and leukaemic myeloblasts, favour a differentiating role for the drug rather than an antimitotic effect.