Serous effusions in monocytic leukaemias
Article first published online: 12 MAR 2008
British Journal of Haematology
Volume 58, Issue 3, pages 547–552, November 1984
How to Cite
Mufti, G. J., Oscier, D. G., Hamblin, T. J., Nightingale, A. and Darlow, S. (1984), Serous effusions in monocytic leukaemias. British Journal of Haematology, 58: 547–552. doi: 10.1111/j.1365-2141.1984.tb04002.x
- Issue published online: 12 MAR 2008
- Article first published online: 12 MAR 2008
- Received 5 April 1984; accepted for publication 19 April 1984
Summary. We report four patients who either presented with or developed serous effusions during the course of monocytic leukaemia. This finding has not been documented previously. All the patients had very high peripheral blood monocyte counts when effusions developed. The effusions resolved after the patients were treated with anti-leukaemic therapy. It is therefore likely that the effusions were disease related. Two of the patients have been treated with raxoxane, one with eptoposide and the other with cytarabine.
Monocytic leukaemias comprise a spectrum of disorders ranging from acute monoblastic leukaemias (AMOL) and acute myelomonocytic leukaemia (AMML) to chronic myelomono-cytic leukaemias (CMML) (Shaw, 1980). Whereas leukaemic infiltration of the gums, central nervous system and skin is well recognized in AMOL and AMML, it is uncommon in CMML (Shaw, 19 78). In contrast to the lymphoid malignancies, leukaemic infiltration of the serosal surfaces giving rise to effusions is rare in both myeloid and monocytic leukaemias and has not been previously documented in CMML. We report four patients with monocytic leukaemia who developed either pleural and/or pericardial effusions or ascites which responded to anti-leukaemic therapy.