Alkaline phosphatase positive precursors of adipocytes in the human bone marrow


Dr P. Bianco. Dipartimento di Biopatologia Umana, Sezione di Anatomia Patologica, Università‘La Sapienza’, Viale Regina Elena 324, (Policlinico), I–00161 Rome, Italy.


Summary Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of ‘reticular’cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.