Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long-term follow-up

  1. Lorna M. Secker-Walker1,†,
  2. Judith M. Chessells2,*,
  3. Elizabeth L. Stewart1,
  4. G. J. Swansbury1,
  5. Susan Richards3,
  6. Sylvia D. Lawler1,‡

Article first published online: 12 MAR 2008

DOI: 10.1111/j.1365-2141.1989.tb07713.x

Issue

British Journal of Haematology

British Journal of Haematology

Volume 72, Issue 3, pages 336–342, July 1989

Additional Information

How to Cite

Secker-Walker, L. M., Chessells, J. M., Stewart, E. L., Swansbury, G. J., Richards, S. and Lawler, S. D. (1989), Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long-term follow-up. British Journal of Haematology, 72: 336–342. doi: 10.1111/j.1365-2141.1989.tb07713.x

Author Information

  1. 1

    Department of Cytogenetics, Royal Marsden Hospital

  2. 2

    Department of Haematology and Oncology, The Hospital for Sick Children, Great Ormond Street

  3. 3

    Clinical Trials Service Unit, Radcliffe Infirmary, Oxford

  1. †

    Department of Haematology. Royal Free Hospital and School of Medicine.

  2. ‡

    Chester Beatty Laboratories, Fulham Road, London.

* Professor Judith M. Chessells, Department of Haematology and Oncology, The Hospital for Sick Children, Great Ormond Street, London WC1N 3JH.

Publication History

  1. Issue published online: 12 MAR 2008
  2. Article first published online: 12 MAR 2008
  3. (Received 5 December 1988; accepted for publication 10 February 1989)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (609K)

Summary. Cytogenetic, clinical and laboratory features at diagnosis were examined in a group of 80 children with acute lymphoblastic leukaemia (ALL) who had been followed up for a minimum of 5 1/2 years. The 17 (21%) with high hyperdiploidy tended to have low leucocyte counts and common ALL, but their favourable outcome (75% event-free survival) was independent of these factors. No patient with hypodiploidy survives while the pseudodiploid and normal groups have an intermediate prognosis. Cytogenetic analysis showed examples of patients with the well-recognized translocations and a number with apparently unique ones. Among the latter were some long-term survivors. We conclude that Cytogenetic analysis identifies a good risk group of patients who remain well on long-term follow-up, but that the presence of a translocation does not necessarily imply a poor outcome.

Get PDF (609K)