Aggressive natural killer cell leukaemia/lymphoma: report of four cases and review of the literature POSSIBLE EXISTENCE OF A NEW CLINICAL ENTITY ORIGINATING FROM THE THIRD LINEAGE OF LYMPHOID CELLS
Article first published online: 7 JUL 2008
British Journal of Haematology
Volume 75, Issue 1, pages 49–56, May 1990
How to Cite
Imamura, N., Kusunoki, Y., Kawa-Ha, K., Yumura, K., Hara, J., Oda, K., Abe, K., Dohy, H., Inada, T., Kajihara, H. and Kuramoto, A. (1990), Aggressive natural killer cell leukaemia/lymphoma: report of four cases and review of the literature POSSIBLE EXISTENCE OF A NEW CLINICAL ENTITY ORIGINATING FROM THE THIRD LINEAGE OF LYMPHOID CELLS. British Journal of Haematology, 75: 49–56. doi: 10.1111/j.1365-2141.1990.tb02615.x
- Issue published online: 7 JUL 2008
- Article first published online: 7 JUL 2008
- Received 4 September 1989; accepted for publication 2 January 1990
The morphologic, immunologic, genotypic and functional properties of peripheral blood and bone marrow cells or cultured cells from four patients with a clinically aggressive non-T, non-B natural killer cell leukaemia/lymphoma (ANKL/L) are described. The leukaemic cells possessed medium to large granules in the cytoplasm, antigens against CD38, CD2, OKIa1 and NKH-1 (CD56) monoclonal antibodies on their cell-surface, and also showed natural killer (NK) activity. In addition, these ANKL/L belonged to neither T- nor B-cell lineage, proved by studying clonal gene rearrangement for the Tβ, Tγ and Tδ receptors, and immunoglobulin.
After comparing them with the seven cases of ANKL/L reported in other institutions, with regard to immunophenotype, genotype and function, we conclude that ANKL/L originating from a third lineage of lymphoid cells is a distinct clinical entity.