Resistance to activated protein C activity of an anti-/2 -glycoprotein I antibody in the presence of β-glycoprotein I


Dr Juzo Matsuda, Department of Medicine. Teikyo University School of Medicine, 11-1, Kaga 2-Chome, Itabashi-Ku, Tokyo 173, Japan.


Some researchers claim that lupus anticoagulant-positive plasma may cause a false-positive reaction in the test for activated protein C (APC) resistance, a hereditary thrombophilic state characterized by abnormal factor V, which frequently causes venous thrombosis, We investigated whether anti-/32 -glycoprotein I antibody (aGPI), which has recently come to be regarded as an anti-cardiolipin antibody (aCL) itself, might have an effect on the APC resistance test.