The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event


Dr Leanne Wiedemann, Leukaemia Research Fund Centre at the Institute of Cancer Research, Chester Beatty Laboratories. 237 Fulham Road, London SW3 6JB.


We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.