• 1
    Amengual, O., Atsumi, T., Khamashta, M.A. & Hughes, G.R.V. (1998) The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thrombosis and Haemostasis, 79, 276281.
  • 2
    Arvieux, J., Darnige, L., Hachulla, E., Roussel, B., Bensa, J.C. & Colomb, M.G. (1996) Species specificity of anti-b2 glycoprotein I autoantibodies and its relevance to anticardiolipin antibody quantitation. Thrombosis and Haemostasis, 75, 725730.
  • 3
    Borrell, M., Sala, N., De Castellanau, C., Lopez, S., Gari, M. & Foncuberta, J. (1992) Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human endothelial cells. Thrombosis and Haemostasis, 68, 268272.
  • 4
    Cariou, R., Tobelem, G., Bellucci, S., Soria, J., Soria, C., Maclouf, J. & Caen, J. (1988) Effect of lupus anticoagulant on antithrombogenic properties of endothelial cells: inhibition of thrombomodulin-dependent protein C activation. Thrombosis and Haemostasis, 60, 5458.
  • 5
    Cuadrado, M.J., López-Pedrera, C., Khamashta, M.A., Camps, M.T., Tinahones, F., Torres, A., Hughes, G.R.V. & Velasco, F. (1997) Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis and Rheumatism, 40, 834841.
  • 6
    Del Papa, N., Guidali, L., Sala, A., Buccellati, C., Khamashta, M.A., Ichikawa, K., Koike, T., Balestrieri, G., Tincani, A., Hughes, G.R.V. & Meroni, P.L. (1997) Endothelial cells as target for antiphospholipid antibodies: human polyclonal and monoclonal anti-β2-glycoprotein I antibodies react in vitro with endothelial cells through adherent β2-glycoprotein I and induce endothelial activation. Arthritis and Rheumatism, 40, 551561.
  • 7
    Exner, T., Rickard, K.A. & Kronenberg, H. (1978) A sensitive test demonstrating lupus anticoagulant and its behavioural patterns. British Journal of Haematology, 40, 143151.
  • 8
    Galli, M., Ruggeri, L. & Barbui, T. (1998) Differential effects of anti-b2-glycoprotein I and antiprothrombin antibodies on the anticoagulant activity of activated protein C. Blood, 91, 19992004.
  • 9
    Harmer, I.J., Loizou, S., Thompson, K.M., So, A.K.L., Walport, M.J. & Mackworth-Young, C. (1995) A human monoclonal antiphospholipid antibody that is representative of serum antibodies and is germline encoded. Arthritis and Rheumatism, 38, 10681076.
  • 10
    Harris, E.N., Gharavi, A.E., Boey, M.L., Patel, B.M., Mackworth-Young, C.G., Loizou, S. & Hughes, G.R. (1983) Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet, ii, 12111214.DOI: 10.1016/S0140-6736(83)91267-9
  • 11
    Harris, E.N. & Pierangeli, S.S. (1994) Antiphospholipid antibodies and the antiphospholipid syndrome. Springer Seminars in Immunopathology, 16, 223245.
  • 12
    Harris, E.N., Pierangeli, S.S. & Birch, D.J. (1994) Anticardiolipin Wet Workshop report: Vth International Symposium on Antiphospholipid Antibodies. American Journal of Clinical Pathology, 101, 616624.
  • 13
    Hasegawa, I., Suzuki, T., Ishii, S., Takakuwa, K. & Tanaka, K. (1994) Establishment of two distinct anti-cardiolipin antibody-producing cell lines from the same individual by Epstein-Barr virus transformation. Thrombosis Research, 74, 7784.DOI: 10.1016/0049-3848(94)90037-X
  • 14
    Hughes, G.R.V. (1993) The antiphospholipid syndrome: ten years on. Lancet, 342, 341344.DOI: 10.1016/0140-6736(93)91477-4
  • 15
    Ichikawa, K., Khamashta, M.A., Koike, T., Matsuura, E. & Hughes, G.R.V. (1994) β2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis and Rheumatism, 37, 14531461.
  • 16
    Kato, H. & Enjyoji, K. (1991) Amino acid sequence and location of the disulfide bonds in bovine β2 glycoprotein I: the presence of five Sushi domains. Biochemistry, 30, 1168711694.
  • 17
    Khamashta, M.A. & Asherson, R.A. (1995) Hughes syndrome: antiphospholipid antibodies move closer to thrombosis in 1994. British Journal of Rheumatology, 34, 493497.
  • 18
    Khamashta, M.A. & Hughes, G.R.V. (1994) Antiphospholipid antibodies: a marker for thrombosis and recurrent abortion. Clinical Reviews in Allergy, 12, 287296.
  • 19
    Kornberg, A., Blank, M., Kaufman, S. & Shoenfeld, Y. (1994) Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. Journal of Immunology, 153, 13281332.
  • 20
    Lu, E.W., Deftos, M., Olee, T., Huang, D.-F., Soto-Gil, R.W., Carson, D.A. & Chen, P.P. (1993) Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis and Rheumatism, 36, 927937.
  • 21
    Malia, R.G., Kitchen, S., Greaves, M. & Preston, F.E. (1990) Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. British Journal of Haematology, 76, 101107.
  • 22
    Marciniak, E. & Romond, E.H. (1989) Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant. Blood, 74, 24262432.
  • 23
    Olee, T.W., Pierangeli, S.S., Handley, H.H., Le, D.T., Wei, X., Lai, C.J., En, J., Novotny, W., Harris, E.N., Woods, V.L., Jr & Chen, P.P. (1996) A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice. Proceedings of the National Academy of Sciences of the United States of America, 93, 86068611.DOI: 10.1073/pnas.93.16.8606
  • 24
    Oosting, J.D., Derksen, R.H.W.M., Bobbink, I.W.G., Hackeng, T.M., Bouma, B.N. & De Groot, P.G. (1993) Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? Blood, 81, 26182625.
  • 25
    Pierangeli, S.S., Barker, J.H., Stikovac, D., Ackerman, D., Anderson, G., Barquinero, J., Acland, R. & Harris, E.N. (1994) Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thrombosis and Haemostasis, 71, 670674.
  • 26
    Pierangeli, S.S., Liu, X., Barker, J.H., Anderson, G. & Harris, E.N. (1995) Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome. Thrombosis and Haemostasis, 74, 13611367.
  • 27
    Pierangeli, S.S., Stewart, M., Silva, L.K. & Harris, E.N. (1998) An Antiphospholipid Wet Workshop: 7th International Symposium on Antiphospholipid Antibodies. Journal of Rheumatology, 25, 156160.
  • 28
    Rand, J.H., Wu, X.X., Andree, H.A.M., Lockwood, C.J., Guller, S., Scher, J. & Harpel, P.C. (1997) Pregnancy loss in the antiphospholipid-antibody syndrome: a possible thrombogenic mechanism. New England Journal of Medicine, 337, 154160.DOI: 10.1056/NEJM199707173370303
  • 29
    Rao, L.V.M., Hoang, A.D. & Rapaport, S.I. (1996) Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid. Blood, 88, 41734182.
  • 30
    Roubey, R.A.S. (1994) Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other ‘antiphospholipid’ autoantibodies. Blood, 84, 28542867.
  • 31
    Roubey, R.A.S. (1996) Immunology of the antiphospholipid antibody syndrome. Arthritis and Rheumatism, 39, 14441454.
  • 32
    Roubey, R.A.S., Eisenberg, R.A., Harper, M.F. & Winfield, J.B. (1995) ‘Anticardiolipin’ autoantibodies recognize β2-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. Journal of Immunology, 154, 954960.
  • 33
    Roubey, R.A.S. & Hoffman, M. (1997) From antiphospholipid syndrome to antibody-mediated thrombosis. Lancet, 350, 14911493.
  • 34
    Sammaritano, L.R., Lockshin, M.D. & Gharavi, A.E. (1992) Antiphospholipid antibodies differ in aPL cofactor requirement. Lupus, 1, 8390.
  • 35
    Santoro, S.A. (1994) Antiphospholipid antibodies and thrombotic predisposition: underlying pathogenetic mechanisms. Blood, 83, 23892391.
  • 36
    Simantov, R., LaSala, J.M., Lo, S.K., Gharavi, A.E., Sammaritano, L.R., Salmon, J.E. & Silverstein, R.L. (1995) Activation of cultured vascular endothelial cells by antiphospholipid antibodies. Journal of Clinical Investigation, 96, 22112219.
  • 37
    Smirnov, M.D., Triplett, D.T., Comp, P.C., Esmon, N.L. & Esmon, C.T. (1995) On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies. Journal of Clinical Investigation, 95, 309316.
  • 38
    Takeya, H., Mori, T., Gabazza, E.C., Kuroda, K., Deguchi, H., Matsuura, E., Ichikawa, K., Koike, T. & Suzuki, K. (1997) Anti-β2-glycoprotein I (β2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the β2GPI binding to phospholipids. Journal of Clinical Investigation, 99, 22602268.
  • 39
    Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N. & Winchester, R.J. (1982) The 1982 revised criteria for the classification of SLE. Arthritis and Rheumatism, 25, 12711277.
  • 40
    Tincani, A., Spatola, L., Prati, E., Allegri, F., Ferremi, P., Cattaneo, R., Meroni, P. & Balestrieri, G. (1996) The anti-β2-clycoprotein I activity in human antiphospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native β2-glycoprotein I and preserved during species evolution. Journal of Immunology, 157, 57325738.
  • 41
    Triplett, D.A. (1993) Antiphospholipid antibodies and thrombosis: a consequence, coincidence, or cause? Archives in Pathology and Laboratory Medicine, 117, 7888.
  • 42
    Willems, G.M., Janssen, M.P., Pelsers, M.M.A.L., Comfurius, P., Galli, M., Zwaal, R.F.A. & Bevers, E.M. (1996) Role of divalency in the high-affinity binding of anticardiolipin antibody–β2-glycoprotein I complexes to lipid membranes. Biochemistry, 35, 1383313842.