A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence
Version of Record online: 21 SEP 2006
British Journal of Haematology
Volume 135, Issue 3, pages 395–404, November 2006
How to Cite
Gifford, S. C., Derganc, J., Shevkoplyas, S. S., Yoshida, T. and Bitensky, M. W. (2006), A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. British Journal of Haematology, 135: 395–404. doi: 10.1111/j.1365-2141.2006.06279.x
- Issue online: 28 SEP 2006
- Version of Record online: 21 SEP 2006
- Received 18 April 2006; accepted for publication 7 July 2006
Figure S1. Evolution of the surface area distribution of a modelled RBC cohort. The initial reticulocyte cohort (curve a, 0 days old) rapidly loses area before the maturation process is complete (curve b, 1.05 days). During the erythrocyte stage, membrane continues to be shed, at a time-dependent rate (see Fig. 5, panel A. iii)). "Instantaneous" distributions of the erythrocyte cohort at an age of 15, 50, 85, 120, and 155 days are shown (curves c through g). Beginning at approximately day 70, red cells are removed from the circulation (see inset), and thus the relative size of the cohort distribution progressively decreases. The mean RBC removal age was taken to be 120 days (see text). The curves shown are selected from thousands of similar, time-specific distributions that, when added together, produce the best fit to the acquired surface area data of Subject X (see Fig. 5, panels A. i and A. ii).
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