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Figure S1. Evolution of the surface area distribution of a modelled RBC cohort. The initial reticulocyte cohort (curve a, 0 days old) rapidly loses area before the maturation process is complete (curve b, 1.05 days). During the erythrocyte stage, membrane continues to be shed, at a time-dependent rate (see Fig. 5, panel A. iii)). "Instantaneous" distributions of the erythrocyte cohort at an age of 15, 50, 85, 120, and 155 days are shown (curves c through g). Beginning at approximately day 70, red cells are removed from the circulation (see inset), and thus the relative size of the cohort distribution progressively decreases. The mean RBC removal age was taken to be 120 days (see text). The curves shown are selected from thousands of similar, time-specific distributions that, when added together, produce the best fit to the acquired surface area data of Subject X (see Fig. 5, panels A. i and A. ii).

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