SEARCH

SEARCH BY CITATION

References

  • Anasetti, C., Lin, A., Nademanee, A., Gluckman, E., Messner, H., Beatty, P., Chauncey, T., Jacobsen, N., Chao, N., Powles, R., Territo, M., Walker, I., Davis, J. & Light, S. (1995) A phase II/III randomized double blind, placebo-controlled multicentre trial of humanised anti-Tac for prevention of acute graft-versus-host disease in recipients of marrow transplantats from unrelated donors. Blood, 86(Suppl. 1), 621a.
  • Antin, J.H., Chen, A.R., Couriel, D.R., Ho, V.T., Nash, R.A. & Weisdorf, D. (2004) Novel approaches to the therapy of steroid resistant acute graft versus host disease. Biology of Blood and Marrow Transplantation, 10, 655668.
  • Aschan, J. (1994) Treatment of moderate to severe acute GvHD: a retrospective analysis. Bone Marrow Transplantation, 14, 601607.
  • Aversa, F., Tabilio, A., Velardi, A., Cunningham, I., Terenzi, A., Falzetti, F., Ruggeri, L., Barbabietola, G., Aristei, C., Latini, P., Reisner, Y. & Martelli, M.F. (1998) Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. New England Journal of Medicine, 339, 11861193.
  • Bacigalupo, A. (2002) Second EBMT Workshop on reduced intensity allogeneic hemopoietic stem cell transplants (RI-HSCT). Bone Marrow Transplantation, 29, 191195.
  • Bacigalupo, A., Mingari, M.C., Moretta, L., Podestà, M., Van Lint, M.T., Piaggio, G., Raffo, M.R. & Marmont, A. (1981) Imbalance of T-cell subpopulations and defective pokeweed mitogen-induced B-cell differentiation after bone marrow transplantation in man. Clinical Immunology and Immunopathology, 20, 137145.
  • Bacigalupo, A., Van Lint, M.T., Occhini, D., Gualandi, F., Lamperelli, T., Sogno, G., Tedone, E., Frassoni, F., Tong, J. & Marmont, A.M. (1991) Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia. Blood, 77, 14231428.
  • Bacigalupo, A., Oneto, R., Bruno, B., Soracco, M., Lamparelli, T., Gualandi, F., Occhini, D., Raiola, A.M., Mordini, N., Berisso, G., Bregante, S., Dini, G., Lombardi, A., Van Lint, M.T. & Brand, R. (1999) Early predictors of transplant-related mortality (TRM) after allogeneic bone marrow transplants (BMT): blood urea nitrogen (BUN) and bilirubin. Bone Marrow Transplantation, 24, 653659
  • Bacigalupo, A., Lamparelli, T., Bruzzi, P., Guidi, S., Alessandrino, P.E., Di Bartolomeo, P., Oneto, R., Bruno, B., Barbanti, M., Sacchi, N., Van Lint, M.T. & Bosi, A. (2001a) Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood, 98, 29422947.
  • Bacigalupo, A., Lamparelli, T., Gualandi, F., Bregante, S., Raiola, A.M., Di Grazia, C., Dominietto, A., Romagnani, C., Occhini, D., Frassoni, F. & Van Lint, M.T. (2001b) Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia: a 10 year follow up of a randomized study. Blood, 98, 31743175.
  • Bacigalupo, A., Oneto, R., Lamparelli, T., Gualandi, F., Bregante, S., Raiola, A.M., Di Grazia, C., Dominietto, A., Romagnani, C., Bruno, B., Van Lint, M.T. & Frassoni, F. (2001c) Pre-emptive therapy of acute graft versus host disease: a pilot study with anti-thymocyte globulin (ATG). Bone Marrow Transplantation, 28, 10931096.
  • Bacigalupo, A., Soriani, M.P., Lamparelli, T., Gualandi, F., Occhini, D., Bregante, S., Raiola, A.M., Di Grazia, C., Dominietto, A., Tedone, E., Piaggio, G., Podesta, M., Bruno, B., Oneto, R., Lombardi, A., Frassoni, F., Rolla, D., Rollandi, G., Viscoli, C., Ferro, C., Garbarono, L. & Van Lint, M.T. (2004) Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation. Haematologica, 89, 12381247.
  • Bacigalupo, A., Lamparelli, T., Barisione, G., Bruzzi, P., Guidi, S., Alessandrino, P.E., Di Bartolomeo, P., Oneto, R., Bruno, B., Sacchi, N., Van Lint, M.T., Bosi, A. Gruppo Italiano Trapianti Midollo Osseo (GITMO). (2006) Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation. Biology of Blood and Marrow Transplantation, 12, 560565.
  • Barrett, A.J., Rezvani, K., Solomon, S., Dickinson, A.M., Wang, X.N., Stark, G., Cullup, H., Jarvis, M., Middleton, P.G. & Chao, N. (2003) New developments in allotransplants immunology. Hematology American Society of Hematology. Education Program, 102, 350371.Review.
  • Bartholomew, A., Sturgeon, C., Siatskas, M., Ferrer, K., McIntoch, K., Patil, S., Hardy, W., Devine, S., Ucker, D., Deans, R., Mosely, A.M., Hoffman, R. & Nchleunng, M. (2002) Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Experimental Hematology, 30, 4248.
  • Basara, N., Blau, W.I., Kiehl, M.G., Schmetzer, B., Bischoff, M., Kirsten, D., Gunzelmann, S. & Fauser, A.A. (2000) Mycophenolate mofetil for the prophylaxis of acute GVHD in HLA-mismatched bone marrow transplant patients. Clinical Transplantation, 14, 121126.
  • Baurmann, H., Bonnefoy-Bérard, N., Thiede, C. Oelschlagel, U., Ehninger, G., Revillard, J.P. & Schwerdtfeger, R. (1999) Clinical and biological effects of ATG used as part of the conditioning in matched unrelated donor (MUD) transplantation. Blood, 94, 134a.
  • Bensinger, W.I., Martin, P.J., Storer, B., Clift, R., Forman, S.J., Negrin, R., Kashyap, A., Flowers, M.E., Lilleby, K., Chancey, T.R., Storb, R. & Appelbaum, F.R. (2001) Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. New England Journal of Medicine, 344, 175181.
  • Blaise, D., Olive, D., Michallet, M., Marit, G., Leblond, V. & Maraninchi, D. (1995) Impairment of leukaemia-free survival by addition of interleukin-2- receptor antibody to standard graft-versus-host prophylaxis. Lancet, 345, 11441146
  • Blaise, D., Kuentz, M. & Container, C. (2000) Randomized trial of bone marrow versus lenograstim primed blood cell allogeneic transplantation. Journal of Clinical Oncology, 18, 537546.
  • Blazar, B.R. (2002) Response of 443 patients to steroids as primary therapy for acute GvHD: comparison of grading systems. Biology of Blood and Marrow Transplantation, 8, 387394.
  • Bolanos-Meade, J. & Vogelsang, G.B. (2005) Novel strategies for steroid-refractory acute graft-versus-host disease. Current Opinion in Hematology, 12, 4044.Review.
  • Bollard, C.M., Gottschalk, S., Huls, M.H., Molldrem, J., Przepiorka, D., Rooney, C.M. & Heslop, H.E. (2006) In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Leukemia & Lymphoma, 47, 837842.
  • Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Traversari, C. & Bordignon, C. (1997) HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science, 276, 17191724.
  • Byrne, J.L., Stainer, C., Cull, G., Haynes, A.P., Bessell, E.M., Hale, G. & Waldmann, H. (2000) The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft-versus-host disease and outcome following unrelated donor bone marrow transplantation for leukaemia. Bone Marrow Transplantation, 25, 411417.
  • Chan, G., Foss, F.M., Roberts, T., Sprague, K., Schenkein, D. & Miller, K.B. (2001) Decreased acute and chronic graft versus host disease with early full donor engraftment following a pentostatin-based preparative regimen for allogeneic bone marrow transplant in high-risk patients. Blood, 98, 383a, (abstr. 1612).
  • Couban, S., Simpson, R., Barnett, M.J. & Bredeson, C. (2002) A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies. Blood, 100, 15251528.
  • Couriel, D., Saliba, R., Hicks, K., Ippoliti, C., De Lima, M., Hosing, C., Khouri, I., Andersson, B., Gajewski, J., Donato, M., Anderlini, P., Kontoyiannis, D.P., Cohen, A., Martin, T., Giralt, S. & Champlin, R. (2004) Tumor necrosis factor alpha blockade for the treatment of acute GVHD. Blood, 104, 649654.
  • Couriel, D.R., Hosing, C., Saliba, R., Shpall, E.J., Anderlini, P., Rhodes, B., Smith, V., Khouri, I., Giralt, S., De Lima, M., Hsu, Y., Ghosh, S., Neumann, J., Andersson, B., Qazilbash, M., Hymes, S., Kim, S., Champlin, R. & Donato, M. (2006) Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD. Blood, 107, 30743080.
  • Cragg, L., Blazar, B.R., Defor, T., Kolatker, N., Miller, W., Kersey, J., Ramsay, M., McGlave, P., Filipovich, A. & Weisdorf, D. (2000) A randomized trial comparing prednisone with antithymocyte globulin/prednisone as an initial systemic therapy for moderately severe acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 6, 441447
  • Deeg, H.J., Blazar, B.R., Bolwell, B.J., Long, G.D., Schuening, F., Cunningham, J., Rifkin, R.M., Abhyankar, S., Briggs, A.D., Burt, R., Lipani, J., Roskos, L.K., White, J.M., Havrilla, N., Schwab, G. & Heslop, H.E. (2001) Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. Blood, 98, 20522058.
  • Dokhelar, M.C., Wiels, J., Lipinski, M., Tetaud, C., Devergie, A., Gluckman, E. & Tursz, T. (1981) Natural killer cell activity in human bone marrow recipients. Early reappearance of peripheral blood natural killer activity in graft versus host disease. Transplantation, 31, 6165.
  • Dominietto, A., Raiola, A.M., Van Lint, M.T., Lamparelli, T., Gualandi, F., Berisso, G., Bregante, S., Frassoni, F., Casarino, L., Verdini, S. & Bacigalupo, A. (2001) Factors influencing haematological recovery after allogeneic haemopoietic stem cell transplants: graft-versus-host disease, donor type, cytomegalovirus infections and cell dose. British Journal of Haematology, 112, 219227.
  • Douek, D.C., McFarland, R.D., Keiser, P.H., Gage, E.A., Massey, J.M., Haynes, B.F., Polis, M.A., Haase, A.T., Feinberg, M.B., Sullivan, J.L., Jamieson, B.D., Zack, J.A., Picker, L.J. & Koup, R.A. (1998) Change in thymic function with age and during the treatment of HIV infection. Nature, 396, 690695.
  • Douek, D.C., Vescio, R.A., Betts, M.R., Brenchley, J.M., Hill, B.J., Zhang, L., Berenson, J.R., Collins, R.H. & Koup, R.A. (2000) Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet, 355, 18751881.
  • El-Badri, N.S., Wang, B.Y. & Good, R.A. (1998) Osteoblast promote engraftment of allogeneic hematopoietic stem cells. Experimental Hematology, 26, 110114.
  • Ferrara, J.L. (2002) Cellular and cytokine effectors of acute graft versus host disease. International Journal of Hematology, 76(Suppl. 1), 195198.
  • Finke, J., Bertz, H., Schmoor, C., Veelken, H., Behringer, D., Wasch, R., Kunzmann, R., Heidecker, L., Lang, H., Meyer-Konig, U. & Mertelsmann, R. (2000) Allogeneic bone marrow transplantation from unrelated donors using in vivo anti-T-cell globulin. British Journal of Haematology, 111, 303313.
  • Garban, F., Drillat, P., Makowski, C., Jacob, M.C., Richard, M.J., Favrot, M., Sotto, J.J., Bensa, J.C. & Cahn, J.Y. (2005) Extracorporeal chemophototherapy for the treatment of graft-versus-host disease: hematologic consequences of short-term, intensive courses. Haematologica, 90, 10961101.
  • Glucksberg, H., Storb, R., Fefer, A., Buckner, C.D., Neiman, P.E., Clift, R.A., Lerner, K.G. & Thomas, E.D. (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation, 18, 295304.
  • Gorgun, G., Alcindor, T., Rao, R. & Foss, F. (2001) Immunologic mechanism of extracorporeal photochemotherapy (ECP) in chronic GVHD. Blood, 98, 650a, (abstr. 2729).
  • Gratwohl, A., Brand, R., Apperley, J., Van Biezen, A., Bandini, G., Devergie, A., Schattenberg, A., Frassoni, F., Guglielmi, C., Iacobelli, S., Michallet, M., Kolb, H.J., Ruutu, T. & Niederwieser, D. (2002) Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia. Blood, 100, 38773886.
  • Greinix, H.T., Socie, G., Bacigalupo, A., Holler, E., Edinger, M.G., Apperley, J.F., Schwarz, T., Ullrich, S.E., Albert, M.L., Knobler, R.M., Peritt, D. & Ferrara, J.L. (2006a) Assessing the potential role of photopheresis in hematopoietic stem cell transplant. Bone Marrow Transplantation, 38, 265273.
  • Greinix, H.T., Knobler, R.M., Worel, N., Schneider, B., Schneeberger, A., Hoecker, P., Mitterbauer, M., Rabitsch, W., Schulenburg, A. & Kalhs, P. (2006b) The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease. Haematologica, 91, 405408.
  • Hansen, J.A., Gooley, T.A., Martin, P.J., Appelbaum, F., Chauncey, T.R., Clift, R.A., Petersdorf, E.W., Radich, J., Sanders, J.E., Storb, R.F., Sullivan, K.M. & Anasetti, C. (1998) Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. New England Journal of Medicine, 338, 962968.
  • Hobbs, J.R., Barrett, A.J., Chambers, D., James, D.C.O., Hugh-Jones, K., Byrom, N., Henry, K. & Lucas, C.F. (1981) Reversal of clinical features of hurler's disease and biochemical improvement after treatment by bone marrow transplantation. Lancet, 3, 709712.
  • Holler, E., Ledderose, G., Knabe, H., Muth, A., Gunther, C., Wilmanns, W. & Kolb, H.J. (1998) ATG serotherapy during pre-transplant conditioning in unrelated donor BMT: dose-dependent modulation of GVHD. Bone Marrow Transplantation, 21, 105a.
  • Holler, E., Kolb, H.J., Mittermuller, J., Kaul, M., Ledderose, G., Duell, Th., Seeber, B., Schleuning, M., Hintermeier-Knabe, R., Ertl, B., Kempeni, J. & Wilmanns, W. (2002) Modulation of acute graft-versus-host disease after allogeneic bone marrow transplantation by tumor necrosis factor α (TNF α) release in the course of pretransplant conditioning: role of conditioning regimens and prophylactic application of a monoclonal antibody neutralizing human TNF α (MAK 195F). Biology of Blood and Marrow Transplantation, 8, 18.
  • Hows, J., Bradley, B., Gore, S. Downie, T., Howard, M. & Gluckman, E. (1993) Prospective evaluation of unrelated donor bone marrow transplantation. Bone Marrow Transplantation, 12, 371380.
  • Hsu, B., May, R., Carrum, G., Krance, R. & Przepiorka, D. (2001) The criteria for steroid-refractory acute graft-versus host disease: an international practice survey. Blood, 98, 663a, (abstr. 2779).
  • Jacobsohn, D.A. & Vogelsang, G.B. Anti-cytokine therapy for the treatment of graft-versus-host disease. Current Pharmaceutical Design, 10, 11951205.
  • Khouri, I.F., Keating, M., Korbling, M., Przepiorka, D., Anderlini, P., Obrien, S., Giralt, S., Ippoliti, C., Von Wolff, B., Gajewski, J., Donato, M., Claxton, D., Ueno, N., Andersson, B., Gee, A. & Champlin, R. (1998) Transplant lite: induction of graft versus malignancy using fludarabine based non ablative chemotherapy and allogeneic blood progenitor cell transplantation as treatment for lymphoid malignances. Journal of Clinical Oncology, 16, 28172824.
  • Klyushnenkova, E.N., Mosca, J. & McIntosh, K.R. (1998) Human mesenchymal stem cells suppress allogeneic T cell responses in vitro: implications for allogeneic transplantation. Blood, 92, 642a.
  • Kottaridis, P.D., Chakraverty, R., Milligan, D.W., Chakrabarti, S., Robinson, S., Chopra, R., Pettengell, R., Marsh, J., Mahendra, P., Schey, S., Morgan, G., Williams, C., Hale, G., Waldmann, H., Linch, D.C., Devereux, S., Glodstone, A.H. & Mackinnon, S. (2000) A non-myeloablative regimen for allogeneic stem cell transplantation with a low incidence of GVHD. Bone Marrow Transplantation, 25, S26.
  • Lan, F., Zeng, D., Higuchi, M., Huie, P., Higgins, J.P. & Strober, S. (2001) Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: ‘‘natural suppressor’’ cells. Journal of Immunology, 167, 20872096.
  • Laughlin, M.J., Barker, J., Bambach, B., Koc, O.N., Rizzieri, D.A., Wagner, J.E., Gerson, S.L., Lazarus, H.M., Cairo, M., Stevens, C.E., Rubinstein, P. & Kurtzberg, J. (2001) Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. New England Journal of Medicine, 344, 18601861.
  • Lazarus, H.M., Koc, O.N., Devine, S.M., Curtin, P., Maziarz, R.T., Holland, H.K., Shpall, E.J., McCarthy, P., Atkinson, K., Cooper, B.W., Gerson, S.L., Laughlin, M.J., Loberiza, Jr, F.R., Moseley, A.B. & Bacigalupo, A. (2005) Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biology of Blood and Marrow Transplantation, 11, 389398.
  • Le Blanc, K., Frassoni, F., Ball, L., Lanino, E., Sundberg, B., Lonnies, L., Roelofs, H., Dini, G., Bacigalupo, A., Locatelli, F., Fibbe, W.F. & Ringden, O. (2006) Mesenchymal stem cells for treatment of severe acute graft-versus-host disease. Blood (ASH Annual Meeting Abstract), 108, 5304a.
  • Lee, K.H., Choi, S.J., Lee, J.H., Lee, J.S., Kim, W.K., Lee, K.B., Sohn, S.K., Kim, J.G., Kim, D.H., Seol, M., Lee, Y.S., Lee, J.H. (2005) Prognostic factors identifiable at the time of onset of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation. Haematologica, 90, 939948.
  • Li, A., Zhang, Q., Jiang, J., Yuan, G., Feng, Y., Hao, J., Li, C., Gao, X., Wang, G. & Xie, S. (2006) Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice. Gene Therapy, 13, 11781187.
  • Locatelli, F., Zecca, M., Rondelli, R., Bonetti, F., Dini, G., Prete, A., Messina, C., Uderzo, C., Ripaldi, M., Porta, F., Giorgiani, G., Giraldi, E. & Pession, A. (2000) Graft versus host disease prophylaxis with low dose cyclosporine reduces the risk of relapse in children with acute leukemia given HLA identical sibling bone marrow transplantation: results of a randomized trial. Blood, 95, 15721579.
  • Lowsky, R., Takahashi, T., Liu, Y.P., Dejbakhsh-Jones, S., Grumet, F.C., Shizuru, J.A., Laport, G.G., Stockerl-Goldstein, K.E., Johnston, L.J., Hoppe, R.T., Bloch, D.A., Blume, K.G., Negrin, R.S. & Strober, S. (2005) Protective conditioning for acute graft-versus-host disease. New England Journal of Medicine, 353, 13211331.
  • MacMillan, M.L., Weisdorf, D.J., Davies, S.M., De For, T.E., Burns, L.J., Ramsay, N.K.C., Wagner, J.E. & Blazar, B.L. (2002) Early antithymocyte globulin therapy improves survival in patients with steroid-resistant acute graft-versus-host disease. Biology of Blood Marrow Transplantation, 8, 4046.
  • Maeda, Y., Reddy, P., Lowler, K.P., Liu, C., Bishop, D.K. & Ferrara, J.L. (2005) Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood, 106, 749755.
  • Marmont, A.M., Horowitz, M.M., Gale, R.P., Sobocinski, K., Ash, R.C., Van Bekkum, D.W., Champlin, R.E., Dicke, K.A., Goldman, J.M. & Good, R.A. (1991) T-cell depletion of HLA-identical transplants in leukemia. Blood, 78, 21202130.
  • Martin, P.J. & Kernan, N.A. (1997) T-cell depletion for GHD prevention in humans. In: Graft-versus-host disease (ed. by J.L.M.Ferrara & H.J.Deeg), pp. 615637. Marcel Dekker: New york.
  • Marty, F.M., Lee, S.J., Fahey, M.M., Alyea, E.P., Soiffer, R.J., Antin, J.H. & Baden, L.R. (2003) Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients. A cohort study. Blood, 102, 27682776.
  • Mc Donald, K.P., Rowe, V., Clouston, A.D., Welply, J.K., Kuns, R.D., Ferrara, J.L., Thomas, R. & Hill, G.R. (2005) Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. Journal of Immunology, 174, 18411850.
  • Mielcarek, M. & Storb, R. (2005) Graft-vs-host disease after non-myeloablative hematopoietic cell transplantation. Leukemia & Lymphoma, 46, 12511260.
  • Mielcarek, M., Burroughs, L., Leisenring, W., Diaconescu, R., Martin, P.J., Sandmaier, B.M., Maloney, D.G., Maris, M.B., Chauncey, T.R., Shizuru, J.A., Blume, K.G., Hegenbart, U., Niederwieser, D., Forman, S., Bruno, B., Woolfrey, A. & Storb, R. (2005) Prognostic relevance of ‘early-onset’ graft-versus-host disease following non-myeloablative haematopoietic cell transplantation. British Journal of Haematology, 129, 381391.
  • Min, D., Taylor, P.A., Panoskaltsis-Mortari, A., Chung, B., Danilenko, D.M., Farrell, C., Lacey, D.L., Blazar, B.R. & Weinberg, K.I. (2002) Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood, 99, 45924600.
  • Minasi, L.E., Kamogawa, Y., Carding, S., Bottomly, K. & Flavell, R.A. (1993) The selective ablation of interleukin 2 producing cells isolated from transgenic mice. Journal of Experimental Medicine, 177, 14511459.
  • Murphy, W.J., Welniak, L.A., Taub, D.D., Wiltrout, R.H., Taylor, P.A., Vallera, D.A., Kopf, M., Young, H., Longo, D.L. & Blazar, B.R. (1998) Differential effects of the absence of interferon-γ and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. Journal of Clinical Investigation, 102, 17421748.
  • Nash, R.A., Antin, J.H., Karanes, C., Fay, J.W., Avalos, B.R., Yeager, A.M. Przepiorka, D., Davies, S., Petersen, F.B., Bartels, P., Buell, D., Fitzsimmons, W., Anasetti, C., Storb, R. & Ratanatharathorn, V. (2000) Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood, 96, 20622068.
  • Nash, R.A., Johnston, L., Parker, P., McCune, J.S., Storer, B., Slattery, J.T., Furlong, T., Anasetti, C., Appelbaum, F.R., Lloid, M.E., Deeg, H.J., Kiem, H.P., Martin, P.J., Schubert, M.M., Witherspoon, R.P., Forman, S.J., Blume, K.G. & Storb, R. (2005) A phase I/II study of mycophenolate mofetil in combination with cyclosporine for prophylaxis of acute graft-versus-host disease after myeloablative conditioning and allogeneic hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation, 11, 495505.
  • Neumann, F., Graef, T., Tapprich, C., Vaupel, M., Steidl, U., Germing, U., Fenk, R., Hinke, A., Haas, R. & Kobbe, G. (2005) Cyclosporine A and mycophenolate mofetil vs cyclosporine A and methotrexate for graft-versus-host disease prophylaxis after stem cell transplantation from HLA-identical siblings. Bone Marrow Transplantation, 35, 10891093.
  • Noel, D.R., Witherspoon, R.B., Storb, R., Atkinson, K., Doney, K., Mickelson, E.M., Ochs, H.D., Warren, R.P., Weiden, P.L. & Thomas, E.D. (1978) Does graft versus host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? An observation on long-term survivors. Blood, 51, 10871105.
  • Ordemann, R., Hutchinson, R., Friedman, J., Burakoff, S.J., Reddy, P., Duffner, U., Braun, T.M., Liu, C., Teshima, T. & Ferrara, J.L. (2002) Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease. Journal of Clinical Investigation, 109, 12491256.
  • Paulin, T., Ringden, O. & Nilsson, B. (1987) Immunological recovery after bone marrow transplantation: role of age, graft versus host disease, prednisolone treatment and infections. Bone Marrow Transplantation, 1, 317328.
  • Peggs, K., Verfuerth, S. & Mackinnon, S. (2001) Induction of cytomegalovirus (CMV)-specific T-cell responses using dendritic cells pulsed with CMV antigen: a novel culture system free of live CMV virions. Blood, 97, 9941000.
  • Perruccio, K., Tosti, A., Burchielli, E., Topini, F., Ruggeri, L., Carotti, A., Capanni, M., Urbani, E., Mancusi, A., Aversa, F., Martelli, M.F., Romani, L. & Velardi, A. (2005) Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood, 106, 43974406.
  • Pittenger, M.F., MacKay, A.M. & Beck, C. (1999) Multilineage potential of adult human mesenchymal stem cells. Science, 284, 143145.
  • Raiola, A.M., Van Lint, M.T., Lamparelli, T., Gualandi, F., Mordini, N., Berisso, G., Bregante, S., Frassoni, F., Sessarego, M., Fugazza, G., Di Stefano, F., Pitto, A. & Bacigalupo, A. (2000) Reduced intensity thiothepa-cyclophosphamide conditioning for allogeneic hemopoietic stem cell transplants (HSCT) in patients up to 60 years of age. British Journal of Haematology, 109, 716721.
  • Ramsay, N.K.C., Kersey, J.H., Robinson, L.L., McGlave, P.B., Woods, W.G., Krivit, W., Kim, T.H., Goldman, A.I. & Nesbit, Jr, M.E. (1982) A randomized study of the prevention of acute graft versus host disease. New England Journal of Medicine, 306, 392397.
  • Rauser, G., Einsele, H., Sinzger, C., Wernet, D., Kuntz, G., Assenmacher, M., Campbell, J.D. & Topp, M.S. (2004) Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood, 103, 35653572.
  • Riddell, S.R., Bleakley, M., Nishida, T., Berger, C. & Warren, E.H. (2006) Adoptive transfer of allogeneic antigen-specific T cells. Biology of Blood and Marrow Transplantation, 12, 912.
  • Ringden, O., Uzunel, M., Rasmusson, I., Remberger, M., Sundberg, B., Lonnies, H., Marschall, H.U., Dlugosz, A., Szakos, A., Hassan, Z., Omazic, B., Aschan, J., Barkholt, L. & Le Blanc, K. (2006) Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation, 81, 13901397.
  • Rocha, V., Wagner, Jr, J.E., Sobocinski, K.A., Klein, J.P., Zhang, M.J., Horowitz, M.M. & Gluckman, E. (2000) Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. New England Journal of Medicine, 342, 18461854.
  • Rocha, V., Cornish, J., Sievers, E.L., Filipovich, A., Locatelli, F., Peters, C., Remberger, M., Michel, G., Arcese, W., Dallorso, S., Tiedemann, K., Busca, A., Chan, K.W., Kato, S., Ortega, J., Vowels, M., Zander, A., Souillet, G., Oakill, A., Woolfrey, A., Pay, A.L., Green, A., Garnier, F., Ionescu, I., Wernet, P., Sirchia, G., Rubinstein, P., Chevret, S. & Gluckman, E. (2001) Comparison of outcomes of unrelated bone marrow and umbelical cord blood transplants in children with acute leukemia. Blood, 97, 29622971.
  • Rowlings, P.A., Przepiorka, D., Klein, J.P., Gale, R.P., Passweg, J.R., Henslee-Downey, P.J., Cahn, J.Y., Calderwood, S., Gratwohl, A., Socie, G., Abecasis, M.M., Sobocinski, K.A., Zhang, M.J. & Horowitz, M.M. (1997) IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. British Journal of Haematology, 97, 855864.
  • Roy, J., McGlave, P.B., Filipovich, A.H., Miller, W.J., Blazar, B.R., Ramsay, N.K., Kersey, J.H. & Weisdorf, D.J. (1992) Acute graft versus-host disease following unrelated donor marrow transplantation: failure of conventional therapy. Bone Marrow Transplantation, 10, 7782.
  • Ruggeri, L., Shlomchik, W.D., Capanni, M., Perruccio, K. & Velardi, A. (2001) Donor-vs-recipient alloreactive NK cells prevent gVHD by killing host APC in MHC disparate hematopoietic transplants. Blood, 98, 813a (abstr. 3378).
  • Russell, J.A., Tran, H.T., Quinlan, D., Chaudhry, A., Duggan, P., Brown, C., Stewart, D., Ruether, J.D., Morris, D., Glick, S., Gyonyor, E. & Andersson, B.S. (2002) Once-daily intravenous busulfan given with fludarabine as conditioning for allogeneic stem cell transplantation: study of pharmacokinetics and early clinical outcomes. Biology of Blood and Marrow Transplantation, 8, 468476.
  • Sale, G.E., Alavaikko, M., Schaefers, K.M. & Mahan, C.T. (1992) Abnormal CD4:CD8 ratios and delayed germinal center reconstitution in lymphnodes of human graft recipients with graft-versus-host disease (GVHD): an immunohistological study. Experimental Hematology, 20, 10171021.
  • Schmitz, N., Beksac, M., Hasenclever, D., Bacigalupo, A., Ruutu, T., Nagler, A., Gluckman, E., Russell, N., Apperley, J.F., Gorin, N.C., Szer, J., Bradstock, K., Buzyn, A., Clark, P., Borkett, K., Gratwohl, A., for the European Group for Blood and Marrow Transplantation. (2002) Transplantation of mobilized peripheral blood cells to HLA identical siblings with standard risk leukaemia. Blood, 100, 761767.
  • Seddik, M., Seemayer, T.A. & Lapp, W.S. (1984) The graft versus host reaction and immune function. T helper cell immunodeficiency associated with graft versus host induced thymic epithelial cell damage. Transplantation, 37, 281286.
  • Shlomchik, W.D., Couzens, M.S., Tang, C.B., McNiff, J., Robert, M.E., Liu, J., Shlomchik, M.J. & Emerson, S.G. (1999) Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science, 285, 412415.
  • Slavin, S., Nagler, A., Naparstek, E., Kapelushnik, Y., Aker, M., Cividalli, G., Varadi, G., Kirschbaum, M., Ackerstein, A., Samuel, S., Amar, A., Brautbar, C., Ben-Tal, O., Eldor, A. & Or, R. (1998) Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood, 91, 756763.
  • Small, T.N., Papadopoulos, E.B., Boulad, F., Black, P., Castro-Malaspina, H., Childs, B.H., Collins, N., Gillio, A., George, D., Jakubowski, A., Heller, G., Fazzari, M., Kernan, N., MacKinnon, S., Szabolcs, P., Young, J.W. & O'Reilly, R.J. (1999) Comparison of immune reconstitution after unrelated and related T-cell depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood, 93, 467480.
  • Sormani, M.P., Oneto, R., Bruno, B., Fiorone, M., Lamparelli, T., Gualandi, F., Raiola, A.M., Dominietto, A., Van Lint, M.T., Frassoni, F., Bruzzi, P. & Bacigalupo, A. (2003) A revised day +7 predictive score for transplant-related mortalità: serum cholinesterase, total protein, blood urea nitrogen, γ glutamil transeferase, donor type and cell dose. Bone Marrow Transplantation, 32, 205211.
  • Storb, R., Deeg, H.J., Whitehead, J., Appelbaum, F., Beatty, P., Bensinger, W., Buckner, C.D., Clift, R., Doney, K., Farewell, V., Hansen, J., Hill, R., Lum, L., Martin, P., McGuffin, R., Sanders, J., Stewart, P., Sullivan, K., Witherspoon, R., Yee, G. & Thomas, E.D. (1986) Marrow transplantation for leukemia: methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of GVHD after marrow transplantation for leukemia. New England Journal of Medicine, 314, 729735.
  • Storb, R., Yu, C., Sanmeier, B.M., Mc Sweeney, P.A., Georges, G., Nash, R.A. & Woolfrey, A. (1999) Mixed hemopoietic chimerism after marrow allografts. Transplantation in the ambulatory care setting. Annals of the New York Academy of Sciences, 872, 372375.
  • Sudres, M., Norol, F., Trenado, A., Gregoire, S., Charlotte, F., Levacher, B., Lataillade, J.J., Bourin, P., Holy, X., Vernant, J.P., Klatzmann, D. & Cohen, J.L. (2006) Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. Journal of Immunology, 176, 77617767.
  • Sykes, M., Szot, G.L., Nguyen, P.L. & Pearson, D.A. (1995) Interleukin-12 inhibits murine graft-versus-host disease. Blood, 86, 24292438.
  • Sykes, M., Pearson, D.A., Taylor, P.A., Szot, G.L., Goldman, S.J. & Blazar, B.R. (1999) Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients. Biology of Blood and Marrow Transplantation, 5, 277284.
  • Teshima, T. & Ferrara, J.L. (2002a) Understanding the alloresponse: new approaches to graft-versus-host disease prevention. Seminars in Hematology, 39, 1522.
  • Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K.R. & Ferrara, J.L. (2002b) Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature, 8, 575581.
  • Trenado, A., Sudres, M., Tang, Q., Maury, S., Charlotte, F., Gregoire, S., Bonyhadi, M., Klatzmann, D., Salomon, B.L. & Cohen, J.L. (2006) Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. Journal of Immunology, 176, 12661273.
  • Tse, W.T., Beyer, W., Pendleton, J.D., D'Andrea, A. & Guinan, E.C. (2000) Bone marrow derived mesenchymal stem cells suppress T cell activation without inducing allogeneic anergy. Blood, 96, 1034a.
  • Uberti, J.P., Ayash, L., Ratanatharathorn, V., Silver, S., Reynolds, C., Becker, M., Reddy, P., Cooke, K.R., Yanik, G., Whitfield, J., Jones, D., Hutchinson, R., Braun, T., Ferrara, J.L. & Levine, J.E. (2005) Pilot trial on the use of etanercept and methylprednisolone as primary treatment for acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 11, 680687.
  • Van Lint, M.T., Uderzo, C., Locasciulli, A., Majolino, I., Scime, R., Locatelli, F., Georgiani, G., Arcese, W., Iori, A.P., Falda, M., Bosi, A., Miniero, R., Alessandrino, P., Dini, G., Rotoli, B. & Bacigalupo, A. (1998) Early treatment of acute graft-versus-host disease with high- or low-dose 6-methylprednisolone: a multicenter randomized trial from the Italian Group for Bone Marrow Transplantation. Blood, 92, 22882293.
  • Van Lint, M.T., Milone, G., Leotta, S., Uderzo, C., Scime, R., Dallorso, S., Locasciulli, A., Guidi, S., Mordini, N., Sica, S., Cudillo, L., Fagioli, F., Selleri, C., Bruno, B., Arcese, W. & Bacigalupo, A. (2006) Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti-thymocyte globulin. Blood, 107, 41774181.
  • Zander, A.R., Zabelina, T., Kroger, N., Renges, H., Kruger, W., Loliger, C., Durken, M., Stockschlader, M., De Wit, M., Wacker-Backhaus, G., Bielack, S., Jaburg, N., Russmann, B., Erttmann, R. & Kabisch, H. (1999) Use of a five-agent GvHD prevention regimen in recipients of unrelated donor marrow. Bone Marrow Transplantation, 23, 889893.
  • Zikos, P., Van Lint, M.T., Frassoni, F., Lamparelli, T., Gualandi, F., Occhini, D., Mordini, N., Berisso, G., Bregante, S., De Stefano, F., Soracco, M., Vitale, V. & Bacigalupo, A. (1998) Low transplant mortality in allogeneic bone marrow transplantation for acute myeloid leukemia: a randomized study of low-dose cyclosporin versus low-dose cyclosporin and low-dose methotrexate. Blood, 91, 35033508.