Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials

Authors


James N. George, MD, Colleges of Medicine and Public Health, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73126-0901, USA. E-mail: james-george@ouhsc.edu

Summary

Health-related quality of life (HRQoL) is a major concern for adults with chronic immune thrombocytopenic purpura (ITP) due to the symptoms associated with the disease and its treatment. This study utilized the ITP-patient assessment questionnaire (ITP-PAQ), a specialized HRQoL questionnaire for ITP, to investigate the humanistic burden of ITP and the impact of romiplostim therapy on HRQoL in two, placebo-controlled, phase 3 clinical trials of splenectomized and non-splenectomized patients. ITP-PAQ was self-administered to ITP patients at baseline, and weeks 4, 12 and 24 of treatment. Splenectomized patients had lower baseline HRQoL scores than non-splenectomized patients in seven of 10 scales (< 0·05). After 24 weeks of romiplostim therapy, splenectomized patients showed significant improvements over placebo in four of 10 ITP-PAQ Scales (Symptoms, = 0·0337; Bother, P = 0·0126; Social Activity, = 0·0145; and Women’s Reproductive Health, = 0·0184). Non-splenectomized patients demonstrated significant improvement over placebo in the Activity Scale (= 0·0458). Data pooled from the two trials, adjusted for splenectomy status, showed significant improvement for romiplostim-treated patients in six scales; Symptoms, Bother, Activity, Fear, Social Activity and Women’s Reproductive Health. These results suggest that adult patients with chronic ITP have improved HRQoL following romiplostim therapy.

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