Both authors contributed equally.
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
Article first published online: 22 SEP 2009
© 2009 Blackwell Publishing Ltd
British Journal of Haematology
Volume 148, Issue 1, pages 3–14, January 2010
How to Cite
Koppen, I. J. N., Hermans, F. J. R. and Kaspers, G. J. L. (2010), Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. British Journal of Haematology, 148: 3–14. doi: 10.1111/j.1365-2141.2009.07898.x
- Issue published online: 14 DEC 2009
- Article first published online: 22 SEP 2009
- acute lymphoblastic leukaemia;
- folate metabolism
Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer, accounting for nearly 30% of all paediatric cancers and 80% of childhood leukaemias. Polymorphisms in folate-related genes may influence the susceptibility to childhood ALL. This review summarizes the results of 14 studies that focussed on the relationship between folate-related gene polymorphisms and the susceptibility to ALL and that fulfilled certain quality criteria. The total group consisted of 729 children and 1821 adults or non age-defined patients. The results of different studies sometimes contradict each other, for which there are several possible explanations. This includes an influence of the type of population studied, because there was a difference between Asian and European study results. Based on several studies, it is plausible that polymorphisms in the MTHFR gene, 677C>T and 1298A>C, are associated with a decreased susceptibility to childhood ALL in non-Asian populations. Polymorphisms in other folate related genes (MTRR, MTR [MS], TYMS [TS], SLC19A1 [RFC1], NNMT, and SHMT1) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited. Further investigations on the relevance of these polymorphisms need to be performed. In general, it is clear that susceptibility to (childhood) ALL is partly related to constitutional differences in folate gene polymorphisms.