The effects of the platinum anti-tumour agents on renal cell kinetics and the response to a second cytotoxic agent

Authors

  • C. Ewen,

    1. Department of Radiobiology, Pater son Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K.
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    • *Amgen Ltd, 272 Science Park, Milton Road, Cambridge CB4 4WE, U.K.

  • J. H. Hendry

    1. Department of Radiobiology, Pater son Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K.
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Abstract

Abstract. Following 15 mg kg-1 cisplatin to mice, the labelling index (LI) in the kidney decreased from 0–4% to & lt;0–01% at 1–3 d, increased to 1–9% at day 16 and returned to control levels by day 30. Cytotoxicity was assessed by counts of viable tubule cross-sections and recovery was incomplete up to 14 months after treatment.

Cisplatin treatment impaired the regeneration response to a dose of 16 mg kg-1 uranyl nitrate (UN) given 14 d after cisplatin when assessed by an increase in LI and sub-capsular tubule count. However, there was recovery with greater time intervals. At nine months after cisplatin there was no difference in response to UN of controls and mice previously treated by cisplatin.

Prior treatment with paraplatin or iproplatin at LD50 doses produced not only no histopathological changes but also no impairment of the subsequent responses to UN.

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