A systematic review of interventions to support looked-after children in school included interventions that aimed to improve attainment, or prevent drop-out or exclusions, and those that aimed to reduce absenteeism in the care population. Studies were critically appraised and their results were considered. No study was found robust enough to provide evidence on effectiveness, but promising interventions were identified. The review highlights the lack of evidence in an area that has received a lot of policy attention in the past few years. Future evaluations need to be underpinned by lessons learned from existing evaluations, clearly defined theories and definitions, and by the views of professionals, researchers, policy-makers and young people in care.