Correlation of skin, nasal and inhalation tests with the IgE in the serum, nasal fluid and sputum


Dr M. Houri, Allergy Research Unit, Benenden Chest Hospital, Benenden, Cran-brook, Kent.


In the course of developing a planned treatment by hyposensitization, still undergoing clinical trials, a system was devised which might be used in assessing respiratory allergies. The sensitivity of the patient assessed by skin, topical nasal instillation and inhalation tests was related to the appearance of IgE-staining cells in the nasal secretion and sputum after a successful challenge test, and the correlation of IgE in the serum and nasal fluid.

The presence of increased eosinophil cell content and the demonstration of IgE in the nasal secretion or sputum associated with a positive clinical response after the challenge test, confirmed the sensitivity to a particular allergen. Raised levels of IgE in the serum of allergic patients corresponded to the size of the skin test reactions but not necessarily to the quantity of IgE appearing in the nasal fluid or sputum.