The significance of food antibodies in familial dysautonomia

Authors

  • B. KLETTER,

    Corresponding author
    1. Pediatric Gastroenterology Research Unit, Shaare Zedek Hospital, Jerusalem; Pediatric Department ‘C’, Chaim Sheba Hospital, Tel Hashomer, and Pediatric Department ‘B’ Central Hospital for the Negev, Beer Sheva
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  • Z. NOACH,

    1. Pediatric Gastroenterology Research Unit, Shaare Zedek Hospital, Jerusalem; Pediatric Department ‘C’, Chaim Sheba Hospital, Tel Hashomer, and Pediatric Department ‘B’ Central Hospital for the Negev, Beer Sheva
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  • Y. ROTEM,

    1. Pediatric Gastroenterology Research Unit, Shaare Zedek Hospital, Jerusalem; Pediatric Department ‘C’, Chaim Sheba Hospital, Tel Hashomer, and Pediatric Department ‘B’ Central Hospital for the Negev, Beer Sheva
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  • S. MOSES,

    1. Pediatric Gastroenterology Research Unit, Shaare Zedek Hospital, Jerusalem; Pediatric Department ‘C’, Chaim Sheba Hospital, Tel Hashomer, and Pediatric Department ‘B’ Central Hospital for the Negev, Beer Sheva
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  • S. FREIER

    1. Pediatric Gastroenterology Research Unit, Shaare Zedek Hospital, Jerusalem; Pediatric Department ‘C’, Chaim Sheba Hospital, Tel Hashomer, and Pediatric Department ‘B’ Central Hospital for the Negev, Beer Sheva
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Dr B. Kletter, Pediatric Gastroenterology Research Unit, Shaare Zedek General Hospital, P.O.B. 293, Jerusalem, Israel.

Summary

Immunological studies have shown that antibodies to cow's milk protein in dysautonomic children are probably due to recurrent aspiration. The immunologicai mechanisms involved do not seem to include reaginic activity but, on the other hand, complement binding Arthus type phenomena probably do occur. There is, therefore, theoretical support for withholding milk protein from dysautonomic children. Our clinical trials were not sufficiently prolonged to prove the usefulness of milk-free diets in practice.

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