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Summary

In vitro lymphocyte transformation and the precipitating antibody to house dust and mite (Dermatophagoides pteronyssinus) extract were studied in mite- and house-dust sensitive patients and in non-atopic individuals. House-dust extract was able to induce a significant [2-14C]thymidine incorporation into lymphocytes from house-dust-sensitive as well as non-allergic individuals. An in vitro response to mite extract, even if less marked, was also seen in most of mite-sensitive patients.

By the micro-Ouchterlony and counterimmunoelectrophoresis techniques anti-dust antibodies were found in the serum of all house-dust-sensitive and non-atopic individuals tested. Anti-mite precipitins were detected in a smaller number of subjects.