Clinical & Experimental Allergy

Effect of disodium cromoglycate on asthmatic reactions to alcoholic beverages

Authors

  • A. B. X. BRESLIN,

    1. Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, London
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  • D. J. HENDRICK,

    1. Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, London
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  • J. PEPYS

    Corresponding author
    1. Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, London
      Professor J. Pepys, Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, Fulham Road, London, S.W.3.
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Professor J. Pepys, Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, Fulham Road, London, S.W.3.

Summary

Eleven asthmatic patients with a history of asthma with or without rhinitis following the ingestion of alcoholic drinks were challenged by oral ingestion of the suspected drink, and some with equivalent amounts of ethyl alcohol. Asthma was provoked in six cases, four having falls in the FEV1 of more than 15%. Three of the latter studied in detail gave immediate asthmatic reactions to the alcoholic beverage, but not to the ethyl alcohol tested by oral ingestion, and in one case by administration through a naso-gastric tube. Pre-treatment by inhalation of disodium cromoglycate inhibited the asthmatic reactions to the alcoholic beverages.

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