Clinical & Experimental Allergy

Farmer's lung: a comparison of simple diagnostic techniques and antigen preparation in human and bovine disease

Authors

  • HEATHER M. DICK,

    Corresponding author
    1. Department of Bacteriology, Glasgow Royal Infirmary, and University of Glasgow, Veterinary School, Bearsden Road, Glasgow
      Dr H. M. Dick, Department of Bacteriology, Royal Infirmary, Castle Street, Glasgow G4 0SF.
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  • CHRISTINE O. DAWSON,

    1. Department of Bacteriology, Glasgow Royal Infirmary, and University of Glasgow, Veterinary School, Bearsden Road, Glasgow
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  • J. D. CAMPBELL

    1. Department of Bacteriology, Glasgow Royal Infirmary, and University of Glasgow, Veterinary School, Bearsden Road, Glasgow
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Dr H. M. Dick, Department of Bacteriology, Royal Infirmary, Castle Street, Glasgow G4 0SF.

Summary

The detection of precipitins to Micropolyspora faeni antigens by simple serological techniques was studied with human and bovine sera. We present data on the relative sensitivities of two gel-diffusion tests, one large-scale, the other using semi-micro methods to conserve antigen in the diagnosis of human and bovine disease. Eight antigenic preparations of M. faeni are described, together with the detailed serology of eight human cases of farmer's lung. The results indicate that the use of more than one antigenic preparation is necessary in any screening programme for the detection of precipitins to M. faeni in either the human or bovine disease.

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