Pulmonary granulomatoses due to inhaled particles: personal experience and some immunological considerations


Professor T. G. Villar, Serviço de Doenças Pulmonares, Hospital de Santa Maria, Lisboa, Portugal.


Clinical, radiological, functional, laboratory and pathologic studies on 114 patients with bronchopulmonary granulomatoses due to inhaled particles are presented, together with measurements of the levels of IgA, IgG and IgM found in the sera of seventy-three of the patients compared with those of forty blood donors used as normal controls. No differences were found between organic or inorganic dusts as causes in any of these parameters. There was, however, a significant increase in IgA and IgG compared with the controls. The possibility of a common pathogenic factor for this disease, independent of the nature of the causal agent is discussed.