Allergens derived from domestic mammals have been investigated by subjecting extracts of cat and dog skin to Sephadex gel filtration and assessing the activity of the eluted fractions by skin tests in appropriate allergic subjects. A certain heterogeneity of allergenic activity occurred and minor allergens, with an estimated molecular weight greater than 70,000, were found which showed activity in patients highly sensitive to cat and dog serum proteins. The major allergens of both mammalian skin extracts were eluted in similar positions between protein markers of 24,000 and 67,000 molecular weight.
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