Clinical & Experimental Allergy

A clinical trial of beclomethasone dipropionate aerosol in children and adolescents with asthma

Authors

  • JOHN MORRISON SMITH

    Corresponding author
    1. Dudley Road Hospital, and The Asthma Clinic, School Health Service, Birmingham
      Dr J. Morrison Smith, 21 Hagley Road West, Birmingham B17 8AL.
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Dr J. Morrison Smith, 21 Hagley Road West, Birmingham B17 8AL.

Summary

A double-blind cross-over trial lasting 4 weeks of beclomethasone dipopionate aerosol in thirty-nine children and young people with asthma already on oral corticosteroid treatment showed a significant beneficial effect which in most cases was maintained on continued open treatment for a further 4 weeks. An overall assessment based on several clinical observations and measurements suggested that twenty-four (62%) were improved while having beclomethasone dipropionate. After a month on known beclomethasone dipropionate fifteen patients had stopped oral corticosteroid treatment and five had reduced the dose without relapse. Response to treatment was not related to total IgE levels. No serious side effects were noted.

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