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Cell mediated hypersensitivity in skin reactions to drugs (except contact dermatitis)

Authors

  • J. H. SAURAT,

    Corresponding author
    1. Laboratoire de Pathologie Experimentale, Faculté de Médecine Necker–Enfants malades, Paris
      Dr J. H. Saurat, Laboratoire de Pathologie expérimentale, Faculté de Médecine Necker–Enfants malades, 156, rue de Vaugirard, 75 730 Paris Cedex 15, France.
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  • C. J. BURTIN,

    1. Laboratoire de Pathologie Experimentale, Faculté de Médecine Necker–Enfants malades, Paris
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  • C. B. SOUBRANE,

    1. Laboratoire de Pathologie Experimentale, Faculté de Médecine Necker–Enfants malades, Paris
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  • J. R. PAUPE

    1. Laboratoire de Pathologie Experimentale, Faculté de Médecine Necker–Enfants malades, Paris
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Dr J. H. Saurat, Laboratoire de Pathologie expérimentale, Faculté de Médecine Necker–Enfants malades, 156, rue de Vaugirard, 75 730 Paris Cedex 15, France.

Summary

The leucocyte migration test (LMT) was used in thirty patients with skin reactions to drugs (except contact dermatitis) together with other diagnostic tests: lymphocyte transformation test (LTT), specific IgE, passive haemagglutination and patch-tests.

The optimal concentrations of drugs for the use of LMT were determined. In all cases in this series, sensitization to the drug considered responsible was confirmed by a positive LTT or by specific IgE. On the contrary, LMT was positive only four times. The value of LMT in detecting allergic reactions to drugs is therefore limited. Out of four positive LMT, three were obtained in patients with bulla formation, showing a definite mononuclear cell infiltration of the basal membrane, suggestive of a cellular mediated mechanism in such drug reactions.

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