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Photo-inactivated allergens

II. Clinical experience with house dust allergen in pulmonary function tests and in immunotherapy

Authors


Dr E. Hénocq, Consultation d'Allergologie, Institut Pasteur-Hôpital, 205, rue de Vaugirard, Paris 15e, France.

Summary

Purified house dust allergen irradiated with UV-light loses its capacity to elicit immediate type skin and bronchial provocation reactions in the majority of asthmatic patients. However, in some patients both immediate and/or late bronchial reactions were observed to the active house dust and its inactivated counterpart.

Immunotherapy with UV-irradiated house dust allergen, which hyposensitized 66% of forty-eight asthmatic patients allergic to house dust, was as effective as treatment with aluminium oxide-adsorbed active house dust, and there were fewer adverse side-effects.

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