Farmer's lung following inhalation of Aspergillus flavus growing in mouldy corn

Authors

  • R. PATTERSON,

    Corresponding author
    1. From the Section of Allergy-Immunology, Department of Medicine and the Department of Pathology, Northwestern University Medical Centre, Chicago, Illinois and the Section of Allergy-Immunology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
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  • H. SOMMERS,

    1. From the Section of Allergy-Immunology, Department of Medicine and the Department of Pathology, Northwestern University Medical Centre, Chicago, Illinois and the Section of Allergy-Immunology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
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  • J. N. FINK

    1. From the Section of Allergy-Immunology, Department of Medicine and the Department of Pathology, Northwestern University Medical Centre, Chicago, Illinois and the Section of Allergy-Immunology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
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Dr R. Patterson, Department of Medicine and Pathology, Northwestern University Medical Centre, Chicago, Illinois, U.S.A.

Summary

After a latent period of 3 weeks following an intense inhalational exposure to mouldy corn, a farmer developed pneumonilis apparently of a hypersensilivity pneumonitis type. This illness was associated with serum precipitating antibodies against antigens in the mouldy corn and against antigens of Aspergillus flavus and fumigatus. The former organism was cultured from the mouldy corn and precipilin bands of identity between an extract of mouldy corn and aspergitlus antigen were demonstrated using the patient's serum. Organizing bronchiolilis oblilerans was found in pulmonary tissue after death occurred, the latter presumably due to pulmonary embolism. This case is believed to represent the occurrence of hypersensitivity pneumonitis following massive inhalation of the spores of the genus A. flavus possibly with transient respiratory infection with these organisms but without systemic invasion of the host.

Ancillary