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Experimental extrinsic allergic alveolitis induced in the guinea-pig with Streptomyces olivaceus


Professor C. R. B. Blackburn, Department of Medicine, University of Sydney, N.S.W. 2006, Australia.


Streptomyces olivaceus was isolated from the roof-thatch of New Guinea huts, and a soluble extract was prepared from it. Using sera from New Guinea natives as a source of precipitating antibody, the S. olivaceus antigen showed a reaction of partial identity with antigens in crude roof-thatch extracts.

The inhalation of aerosols of S. olivaceus antigen by guinea-pigs, previously given parenteral doses of the same antigenic solution, induced extrinsic allergic alveolitis.

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