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Clinical & Experimental Allergy

Effect of alpha receptor blocking drug, thymoxamine, on allergen induced bronchoconstriction in extrinsic asthma

Authors

  • K. R. PATEL,

    Corresponding author
    1. Department of Respiratory Medicine, Western Infirmary & Knights wood Hospital, Glasgow G13 2XG
      K. R. Patel. Centre for Respiratory Investigation, Glasgow Royal Infirmary, Glasgow GH OSF.
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  • J. W. KERR

    1. Department of Respiratory Medicine, Western Infirmary & Knights wood Hospital, Glasgow G13 2XG
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K. R. Patel. Centre for Respiratory Investigation, Glasgow Royal Infirmary, Glasgow GH OSF.

Summary

In ten patients with extrinsic bronchial asthma, allergen provoked bronchospasm was significantly inhibited by the alpha receptor blocking drug thymoxamine given intravenously. In two of these patients thymoxamine by inhalation also effectively inhibited allergen induced broncboconsiriction. It is suggested that thymoxamine may be acting either by increasing intracellular levels of cyclic AMP and thus inhibiting mediator release following allergen challenge or by modifying the airways response to these mediators by altering the bronchomotor tone. The variable responses recorded after allergen challenge in presence of alpha blockade with thymoxamine suggests that the dominant effect is on the bronchomotor tone rather than the mediator release.

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