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Clinical & Experimental Allergy

Extrinsic allergic alveolitis due to rat serum proteins


Professor J. Pepys, Department of Clinical Immunology, Cardiothoracic Institute, Brampton, London SW3.


In a research assistant with recurrent episodes of extrinsic allergic alveolitis on exposure to rats, typical systemic and pulmonary reactions on inhalation and positive reaction on prick testing were elicited only by tests with rat serum; precipitins were present against rat serum and rat pelt, but not rat fur, and were also present against rat urine, which may contain large amounts of serum protein and which may haw been a main source of antigenic exposure.

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