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Antibodies mediating type I skin test reactions to polysaccharide and protein antigens of Candida albicans

Authors

  • JOAN L. LONGBOTTOM,

    1. Department of Clinical Immunology, Cardiothoracic Institute, University of London, Brompton Hospital, London
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  • W. D. BRIGHTON,

    1. Laboratory for Allergens, National Institute for Biological Standards and Control, Holly Hill, Hampstead, London
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  • GERALDINE EDGE,

    1. Department of Clinical Immunology, Cardiothoracic Institute, University of London, Brompton Hospital, London
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  • J. PEPYS

    Corresponding author
    1. Department of Clinical Immunology, Cardiothoracic Institute, University of London, Brompton Hospital, London
      Professor J. Pepys, Cardiothoracic Institute, Brompton Hospital, London SW3.
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Professor J. Pepys, Cardiothoracic Institute, Brompton Hospital, London SW3.

Summary

Immediate, type I, prick test reactions in man to purified fractions of Candida albicans group A were mediated by different classes of antibody. The allergens were the cell-wall polysaccharide, mannan, and a ‘purified’ cytoplasmic protein fraction, free of mannan, prepared by passage through Sepharose-concanavalin-A. Passive transfer tests in the monkey gave immediate reactions, (1) to the purified, cytoplasmic, protein mediated by heat-labile long-term sensitizing antibody, and (2) to the polysaccharide, mannan, mediated by heat-stable short-term sensitizing antibody.

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