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Clinical & Experimental Allergy

The IgG subclasses of antibodies to grass pollen allergens produced in hay fever patients during hyposensitization

Authors

  • M. E. DEVEY,

    Corresponding author
    1. Immunology Division, Department of Pathology, University of Cambridge and Beecham Research Laboratories, Brockham Park, Betchworth, Surrey
      Dr M. E. Devey, Division of Immunology, Department of Pathology, Laboratories Block, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ.
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  • D. V. WILSON,

    1. Immunology Division, Department of Pathology, University of Cambridge and Beecham Research Laboratories, Brockham Park, Betchworth, Surrey
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  • A. W. WHEELER

    1. Immunology Division, Department of Pathology, University of Cambridge and Beecham Research Laboratories, Brockham Park, Betchworth, Surrey
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Dr M. E. Devey, Division of Immunology, Department of Pathology, Laboratories Block, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ.

Summary

Total IgG, IgG subclass and IgE antibodies specific for grass pollen allergens were measured by the red cell linked antigen-antiglobulin reaction (RCLAAR) in serum samples from nineteen patients who had undergone a course of hyposensitization. Increases in both specific IgG and IgE antibodies were seen after treatment in most patients. In the IgG subclasses the predominant response was for IgG1 and IgG4 antibodies. Attempts were made to correlate the antibody responses with the clinical response and the results are discussed with reference to the possible mechanisms of hyposensitization.

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