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Elevated serum IgG4 levels in cystic fibrosis patients


Dr F. Shakib, Department of Experimental Pathology, The Medical School, University of Birmingham, Birmingham.


The quantitative measurement of the IgG subclass composition of the sera from sixteen patients with cystic fibrosis has revealed grossly elevated levels of IgG4 in seven patients. The possible significance of this observation is discussed in relation to recent reports of a high incidence of immediate-type hypersensitivity in such patients.

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