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Clinical & Experimental Allergy

The protective effect of inhaled BRL 10833 on allergen induced bronchospasm


Dr R. Pauwels, Department of Chest Diseases, Academic Hospital, De Pintelaan 135, 9000 Ghent, Belgium.


BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. A significant protective effect of BRL 10833 on the immediate bronchial reaction was seen in five out of ten patients. A single inhalation of 40 mg BRL 10833 seems also to have some protective effect on the late bronchial reaction, following an immediate reaction.

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