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Clinical & Experimental Allergy

The protective effect of inhaled BRL 10833 on allergen induced bronchospasm

Authors


Dr R. Pauwels, Department of Chest Diseases, Academic Hospital, De Pintelaan 135, 9000 Ghent, Belgium.

Summary

BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. A significant protective effect of BRL 10833 on the immediate bronchial reaction was seen in five out of ten patients. A single inhalation of 40 mg BRL 10833 seems also to have some protective effect on the late bronchial reaction, following an immediate reaction.

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