ACTH gel was used as a treatment for hay fever during the 1972–1974 hay fever seasons. Patients suffering from hay fever were given ACTH in different dose schedules and other hay fever patients were used as controls.
Subjectively, those treated with ACTH gel were pleased with the results and reported more favourably on the injections than those receiving placebo. Objectively, using presence of any symptoms as the index of measurement, those treated with ACTH gel (80 units once weekly or 80 units twice weekly) had a significantly lower incidence of hay fever. Side effects were few.