Clinical & Experimental Allergy

A comparative trial of hyposensitization in 1973 in the treatment of hay fever using Pollinex and Alavac-P

Authors

  • A. C. M. L. MILLER

    Corresponding author
    1. E.N.T. Department, Belfast City Hospital, Belfast, Northern Ireland
      Dr A. C. M. L. Miller, E.N.T. Department, Belfast City Hospital, Belfast, Northern Ireland.
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Dr A. C. M. L. Miller, E.N.T. Department, Belfast City Hospital, Belfast, Northern Ireland.

Summary

A direct comparison was made in 112 hay fever patients of hyposensitization treatment with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex) and with alum-precipitated pyridine extract (Alavac-P) which is an accepted form of treatment, its efficacy having been shown by a comparative trial against a placebo preparation.

No significant difference could be detected between the results of the two forms of treatment. Seventy-seven per cent of patients responded with improvement following treatment with the tyrosine adsorbed vaccine, and 81% of those receiving the alum-precipitated vaccine. Side effects from treatment, both local and general, were generally of an infrequent or mild nature for both vaccines.

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