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Clinical & Experimental Allergy

Extrinsic allergic alveolitis from bird exposure

Studies on the immediate hypersensitivity reaction

Authors

  • C. P. W. WARREN,

    Corresponding author
    1. Departments of Medicine and Immunology, Faculty of Medicine and the Medical Research Council Group for Allergy Research, University of Manitoba, Winnipeg, Manitoba, Canada
      Dr C. P. W. Warren, Clinical Investigation Unit, St Boniface General Hospital, 409 Tache Avenue, Manitoba R2H 2A6, Canada.
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  • R. M. CHERNIACK,

    1. Departments of Medicine and Immunology, Faculty of Medicine and the Medical Research Council Group for Allergy Research, University of Manitoba, Winnipeg, Manitoba, Canada
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  • K. S. TSE

    1. Departments of Medicine and Immunology, Faculty of Medicine and the Medical Research Council Group for Allergy Research, University of Manitoba, Winnipeg, Manitoba, Canada
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Dr C. P. W. Warren, Clinical Investigation Unit, St Boniface General Hospital, 409 Tache Avenue, Manitoba R2H 2A6, Canada.

Summary

Six patients with extrinsic allergic alveolitis had weak immediate and strong late reactions to intracutaneous injection of bird serum. Biopsy of the late reaction revealed vasculitis and immunoglobulin and complement deposition in one. The antibody responsible for the immediate hypersensitivity could be transferred in serum. It was short lasting (4 hr) and resistant to heat and 2-mercaptoethanol. No evidence of an immediate reaction in the lungs could be detected following inhalation challenge as judged by examination of spirometry, flow volume loops and single breath nitrogen washout curves.

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