This paper was presented in part at the 32nd annual meeting of the American Academy of Allergy, San Juan, Puerto Rico, March 1976.
Treatment of ragweed hay fever with intranasally administered disodium cromoglycate*
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 7, Issue 6, pages 569–576, November 1977
How to Cite
CRAIG, S., RUBINSTEIN, E., REISMAN, R. E. and ARBESMAN, C. E. (1977), Treatment of ragweed hay fever with intranasally administered disodium cromoglycate. Clinical & Experimental Allergy, 7: 569–576. doi: 10.1111/j.1365-2222.1977.tb01487.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
In a double-blind study the therapeutic effect of a 4% disodium cromoglycate (DSCG) nasal solution was evaluated in thirty-nine patients with acute symptoms of ragweed hay fever. Patients were randomly assigned to the DSCG or placebo group as they presented with allergic rhinitis. Overall, the DSCG was not more effective than placebo in controlling the symptoms of rhinitis or in decreasing the need for concomitant antihistamines or corticosteroids. Among patients with the highest pretreatment serum ragweed-specific IgE (RW IgE) levels, drug-treated patients had some reduction in symptoms as compared to their placebo controls during the peak of the ragweed pollen season. DSCG treatment did not influence the usual seasonal rise in RW IgE. Side effects from both the active and placebo aerosols were frequent but mild.
We conclude that DSCG nasal solution used for the treatment of seasonal ragweed allergic rhinitis is relatively ineffective.