RAST in the diagnosis of hypersensitivity to dog and cat allergens A comparison of different extract preparations with clinical history, skin test and provocation tests

Authors

  • B. WÜTHRICH,

    Corresponding author
    1. Allergy Station, Department of Dermatology, University Hospital Zürich, Switzerland, and Clinical Research, Pharmacia Diagnostics AB, Uppsala, Sweden
      Dr B. Wüthrich, Allergy Station, Department of Dermatology, University Hospital, Gloriastrasse 31, CH 8091 Zürich, Switzerland.
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  • H. ARRENDAL

    1. Allergy Station, Department of Dermatology, University Hospital Zürich, Switzerland, and Clinical Research, Pharmacia Diagnostics AB, Uppsala, Sweden
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Dr B. Wüthrich, Allergy Station, Department of Dermatology, University Hospital, Gloriastrasse 31, CH 8091 Zürich, Switzerland.

Summary

A comparison was made of clinical signs and provocation tests with the RAST for allergy to dog in eight and cat in twenty patients. Twenty-two had high IgE levels and all gave positive reactions to provocation tests. A commercially available dog epithelium extract gave more positive RASTs than five other dog allergen preparations, and there were no positive reactions to dog serum. The RAST was negative in patients with a low degree of sensitivity. All twenty patients allergic to cat gave positive intracutaneous test reactions and in the RAST the cat epithelial allergen showed 90% agreement with the in vivo findings.

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