Clinical & Experimental Allergy

HLA haplotypes and hayfever: a possible protective role

Authors

  • C. M. GWYNN,

    Corresponding author
    1. Birmingham Chest Clinic, Birmingham, and Regional Blood Transfusion Service, Birmingham.
      Dr C. M. Gwynn, Birmingham Chest Clinic, 151 Great Charles Street, Queensway, Birmingham B3 3HX.
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  • PAULINE MACKINTOSH

    1. Birmingham Chest Clinic, Birmingham, and Regional Blood Transfusion Service, Birmingham.
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Dr C. M. Gwynn, Birmingham Chest Clinic, 151 Great Charles Street, Queensway, Birmingham B3 3HX.

Summary

The HLA haplotype frequencies of European asthmatic children and their immediate families were studied, and a disassociation between haplotype A1-B8 and skin sensitivity to grass pollens was found, suggesting that within this allergic population, possession of the haplotype A1-B8 conferred possible protection against grass pollinosis. There was no association between A1-B8 and clinical asthma or between it and skin sensitivity to the house dust mite.

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