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Clinical & Experimental Allergy

Airflow obstruction in asthma induced by inhalation of small minimum doses of allergen

Authors

  • Y. KURIMOTO,

    1. Allergy Clinic, Kobe Medical Association, and Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
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  • S. KURIMOTO

    Corresponding author
    1. Anaesthesia Department, Osaka Medical School, Takatsuki, Osaka, Japan
      Dr Y. Kurimoto, Allergy Clinic, Kobe Medical Association, Kusunokicho 3-chome, Ikutaku, Kobe 650, Japan.
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Dr Y. Kurimoto, Allergy Clinic, Kobe Medical Association, Kusunokicho 3-chome, Ikutaku, Kobe 650, Japan.

Summary

In order to define allergen-induced bronchial responses, sixteen asthmatics, assessed as mild (twelve cases) and moderate (four cases) were tested by inhalation of small doses of house dust allergen. The minimum dose was first determined in each patient. It caused no abnormal respiratory sensation, while a fall of V̇max50 air with no change or slight decrease of V̇max50 He-O2 and a rise of density dependence ratio were observed. Inhalation tests with multiples of the minimum dose were made and showed that the minimum dose was dependent on the individual, his condition and induced airflow obstruction in a dose-related fashion.

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