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Clinical & Experimental Allergy

Angioedema responding to antiprotease treatment but without abnormalities of the complement system

Authors

  • D. L. J. FREED,

    Corresponding author
    1. Department of Immunology, United Manchester Hospitals, and Department of Medicine, Guy's Hospital, London
      Dr D. L. J. Freed, Department of Bacteriology & Virology, Manchester University, M13 9PT.
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  • P. D. BUISSERET,

    1. Department of Immunology, United Manchester Hospitals, and Department of Medicine, Guy's Hospital, London
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    • *

      Louisiana State University Medical Center, 1542 Tulane Ave., New Orleans, Louisiana 70112, U.S.A.

  • MARY J. LLOYD,

    1. Department of Immunology, United Manchester Hospitals, and Department of Medicine, Guy's Hospital, London
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  • R. S. H. PUMPHREY,

    1. Department of Immunology, United Manchester Hospitals, and Department of Medicine, Guy's Hospital, London
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  • M. GARRETTS

    1. Department of Immunology, United Manchester Hospitals, and Department of Medicine, Guy's Hospital, London
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Dr D. L. J. Freed, Department of Bacteriology & Virology, Manchester University, M13 9PT.

Summary

Four patients suffered from chronic or recurrent angioedema, of sudden onset in adult life, associated with visceral pain and impossible to control by dietary means. In spite of normal complement function they respond very well to tranexamic acid therapy. Antiprotease drugs need not be restricted to cases of ClsINH deficiency.

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