Effect of FPL57787 in exercise-induced asthma


Dr Neil C. Thomson, Department of Respiratory Medicine, Western Infirmary, Glasgow, G11 6NT.


In ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double-blind fashion to assess the effect of FPL57787 in preventing exercise-induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to 8 min. FPL57787 gave significant protection (P < 0.01) compared to placebo from the maximum percentage fall in FEV1, FVC and MMEF after exercise. FPL57787 also produced a small but significant (P < 0.01) percentage increase in FEV1, 2 hr after the drug compared to placebo, whereas no significant increase was seen in FVC or in MMEF.